PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

The Published Kinase Inhibitor Set (PKIS) is a publicly-available chemogenomic library distributed to more than 300 laboratories by GlaxoSmithKline (GSK) between 2011 and 2015 and by SGC-UNC from 2015 to 2017. Screening this library of well-annotated, published kinase inhibitors has yielded a pletho...

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Detalles Bibliográficos
Autores principales: Tamir, Tigist Y., Drewry, David H., Wells, Carrow, Major, M. Ben, Axtman, Alison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522982/
https://www.ncbi.nlm.nih.gov/pubmed/32985588
http://dx.doi.org/10.1038/s41598-020-72869-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522982/
https://www.ncbi.nlm.nih.gov/pubmed/32985588
http://dx.doi.org/10.1038/s41598-020-72869-9

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