Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early infection. A switch to X4-tropism often occurs during the course of infection. X4-tropism switching is strongly associated with ac...

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Detalles Bibliográficos
Autores principales: Connell, Bridgette J., Hermans, Lucas E., Wensing, Annemarie M. J., Schellens, Ingrid, Schipper, Pauline J., van Ham, Petra M., de Jong, Dorien T. C. M., Otto, Sigrid, Mathe, Tholakele, Moraba, Robert, Borghans, José A. M., Papathanasopoulos, Maria A., Kruize, Zita, Venter, Francois W. D., Kootstra, Neeltje A., Tempelman, Hugo, Tesselaar, Kiki, Nijhuis, Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522993/
https://www.ncbi.nlm.nih.gov/pubmed/32985522
http://dx.doi.org/10.1038/s41598-020-71699-z

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