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Protective role of mirtazapine in adult female Mecp2(+/−) mice and patients with Rett syndrome

BACKGROUND: Rett syndrome (RTT), an X-linked neurodevelopmental rare disease mainly caused by MECP2-gene mutations, is a prototypic intellectual disability disorder. Reversibility of RTT-like phenotypes in an adult mouse model lacking the Mecp2-gene has given hope of treating the disease at any age....

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Detalles Bibliográficos
Autores principales:	Flores Gutiérrez, Javier, De Felice, Claudio, Natali, Giulia, Leoncini, Silvia, Signorini, Cinzia, Hayek, Joussef, Tongiorgi, Enrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523042/ https://www.ncbi.nlm.nih.gov/pubmed/32988385 http://dx.doi.org/10.1186/s11689-020-09328-z

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