Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection in vivo

SARS-CoV-2, the causative agent of COVID-19, is responsible for over 24 million infections and 800,000 deaths since its emergence in December 2019. There are few therapeutic options and no approved vaccines. Here we examine the properties of highly potent human monoclonal antibodies (hu-mAbs) in a m...

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Detalles Bibliográficos
Autores principales: Schäfer, Alexandra, Muecksch, Frauke, Lorenzi, Julio C. C., Leist, Sarah R., Cipolla, Melissa, Bournazos, Stylianos, Schmidt, Fabian, Gazumyan, Anna, Baric, Ralph S., Robbiani, Davide F., Hatziioannou, Theodora, Ravetch, Jeffrey V., Bieniasz, Paul D., Nussenzweig, Michel C., Sheahan, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523108/
https://www.ncbi.nlm.nih.gov/pubmed/32995782
http://dx.doi.org/10.1101/2020.09.15.298067

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