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Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspread...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523134/ https://www.ncbi.nlm.nih.gov/pubmed/32995765 http://dx.doi.org/10.21203/rs.3.rs-69657/v1 |
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author | Lee, Hye Kyung Knabl, Ludwig Pipperger, Lisa Volland, Andre Furth, Priscilla Kang, Keunsoo Smith, Harold Knabl, Ludwig Bellmann, Romuald Bernhard, Christina Kaiser, Norbert Gänzer, Hannes Ströhle, Mathias Walser, Andreas Von Laer, Dorothee Hennighausen, Lothar |
author_facet | Lee, Hye Kyung Knabl, Ludwig Pipperger, Lisa Volland, Andre Furth, Priscilla Kang, Keunsoo Smith, Harold Knabl, Ludwig Bellmann, Romuald Bernhard, Christina Kaiser, Norbert Gänzer, Hannes Ströhle, Mathias Walser, Andreas Von Laer, Dorothee Hennighausen, Lothar |
author_sort | Lee, Hye Kyung |
collection | PubMed |
description | To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease impacting immunological activation were included (Cystic Fibrosis (CF), Nuclear factor-kappa B Essential Modulator (NEMO) deficiency). CF, but not NEMO, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection (IL1B, IL17A, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease illustrated the pathophysiological importance of context on impact of immunological response. |
format | Online Article Text |
id | pubmed-7523134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Journal Experts |
record_format | MEDLINE/PubMed |
spelling | pubmed-75231342020-09-30 Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community Lee, Hye Kyung Knabl, Ludwig Pipperger, Lisa Volland, Andre Furth, Priscilla Kang, Keunsoo Smith, Harold Knabl, Ludwig Bellmann, Romuald Bernhard, Christina Kaiser, Norbert Gänzer, Hannes Ströhle, Mathias Walser, Andreas Von Laer, Dorothee Hennighausen, Lothar Res Sq Article To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease impacting immunological activation were included (Cystic Fibrosis (CF), Nuclear factor-kappa B Essential Modulator (NEMO) deficiency). CF, but not NEMO, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection (IL1B, IL17A, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease illustrated the pathophysiological importance of context on impact of immunological response. American Journal Experts 2020-09-23 /pmc/articles/PMC7523134/ /pubmed/32995765 http://dx.doi.org/10.21203/rs.3.rs-69657/v1 Text en This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Lee, Hye Kyung Knabl, Ludwig Pipperger, Lisa Volland, Andre Furth, Priscilla Kang, Keunsoo Smith, Harold Knabl, Ludwig Bellmann, Romuald Bernhard, Christina Kaiser, Norbert Gänzer, Hannes Ströhle, Mathias Walser, Andreas Von Laer, Dorothee Hennighausen, Lothar Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community |
title | Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community |
title_full | Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community |
title_fullStr | Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community |
title_full_unstemmed | Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community |
title_short | Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community |
title_sort | immune transcriptomes of highly exposed sarscov-2 asymptomatic seropositive versus seronegative individuals from the ischgl community |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523134/ https://www.ncbi.nlm.nih.gov/pubmed/32995765 http://dx.doi.org/10.21203/rs.3.rs-69657/v1 |
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