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Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspread...

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Autores principales: Lee, Hye Kyung, Knabl, Ludwig, Pipperger, Lisa, Volland, Andre, Furth, Priscilla, Kang, Keunsoo, Smith, Harold, Bellmann, Romuald, Bernhard, Christina, Kaiser, Norbert, Gänzer, Hannes, Ströhle, Mathias, Walser, Andreas, Von Laer, Dorothee, Hennighausen, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523134/
https://www.ncbi.nlm.nih.gov/pubmed/32995765
http://dx.doi.org/10.21203/rs.3.rs-69657/v1
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author Lee, Hye Kyung
Knabl, Ludwig
Pipperger, Lisa
Volland, Andre
Furth, Priscilla
Kang, Keunsoo
Smith, Harold
Knabl, Ludwig
Bellmann, Romuald
Bernhard, Christina
Kaiser, Norbert
Gänzer, Hannes
Ströhle, Mathias
Walser, Andreas
Von Laer, Dorothee
Hennighausen, Lothar
author_facet Lee, Hye Kyung
Knabl, Ludwig
Pipperger, Lisa
Volland, Andre
Furth, Priscilla
Kang, Keunsoo
Smith, Harold
Knabl, Ludwig
Bellmann, Romuald
Bernhard, Christina
Kaiser, Norbert
Gänzer, Hannes
Ströhle, Mathias
Walser, Andreas
Von Laer, Dorothee
Hennighausen, Lothar
author_sort Lee, Hye Kyung
collection PubMed
description To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease impacting immunological activation were included (Cystic Fibrosis (CF), Nuclear factor-kappa B Essential Modulator (NEMO) deficiency). CF, but not NEMO, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection (IL1B, IL17A, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease illustrated the pathophysiological importance of context on impact of immunological response.
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spelling pubmed-75231342020-09-30 Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community Lee, Hye Kyung Knabl, Ludwig Pipperger, Lisa Volland, Andre Furth, Priscilla Kang, Keunsoo Smith, Harold Knabl, Ludwig Bellmann, Romuald Bernhard, Christina Kaiser, Norbert Gänzer, Hannes Ströhle, Mathias Walser, Andreas Von Laer, Dorothee Hennighausen, Lothar Res Sq Article To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease impacting immunological activation were included (Cystic Fibrosis (CF), Nuclear factor-kappa B Essential Modulator (NEMO) deficiency). CF, but not NEMO, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection (IL1B, IL17A, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease illustrated the pathophysiological importance of context on impact of immunological response. American Journal Experts 2020-09-23 /pmc/articles/PMC7523134/ /pubmed/32995765 http://dx.doi.org/10.21203/rs.3.rs-69657/v1 Text en This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Lee, Hye Kyung
Knabl, Ludwig
Pipperger, Lisa
Volland, Andre
Furth, Priscilla
Kang, Keunsoo
Smith, Harold
Knabl, Ludwig
Bellmann, Romuald
Bernhard, Christina
Kaiser, Norbert
Gänzer, Hannes
Ströhle, Mathias
Walser, Andreas
Von Laer, Dorothee
Hennighausen, Lothar
Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_full Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_fullStr Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_full_unstemmed Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_short Immune transcriptomes of highly exposed SARSCoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
title_sort immune transcriptomes of highly exposed sarscov-2 asymptomatic seropositive versus seronegative individuals from the ischgl community
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523134/
https://www.ncbi.nlm.nih.gov/pubmed/32995765
http://dx.doi.org/10.21203/rs.3.rs-69657/v1
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