Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801

All known recently emerged human coronaviruses likely originated in bats. Here, we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged human coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2) and two highly relevant...

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Detalles Bibliográficos
Autores principales: Wahl, Angela, Gralinski, Lisa, Johnson, Claire, Yao, Wenbo, Kovarova, Martina, Dinnon, Kenneth, Liu, Hongwei, Madden, Victoria, Krzystek, Halina, De, Chandrav, White, Kristen, Schäfer, Alexandra, Zaman, Tanzila, Leist, Sarah, Grant, Paul, Gully, Kendra, Askin, Frederic, Browne, Edward, Jones, Corbin, Pickles, Raymond, Baric, Ralph, Garcia, J Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523135/
https://www.ncbi.nlm.nih.gov/pubmed/32995766
http://dx.doi.org/10.21203/rs.3.rs-80404/v1

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