Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics

SARS-CoV-2 is causing a pandemic with currently > 29 million confirmed cases and > 900,000 deaths worldwide. The locations and mechanisms of virus entry into the human respiratory tract are incompletely characterized. We analyzed publicly available RNA microarray datasets for SARS-CoV-2 entry...

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Autores principales: Matusiak, Magdalena, Schürch, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523260/
https://www.ncbi.nlm.nih.gov/pubmed/32993656
http://dx.doi.org/10.1186/s12931-020-01521-x
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author Matusiak, Magdalena
Schürch, Christian M.
author_facet Matusiak, Magdalena
Schürch, Christian M.
author_sort Matusiak, Magdalena
collection PubMed
description SARS-CoV-2 is causing a pandemic with currently > 29 million confirmed cases and > 900,000 deaths worldwide. The locations and mechanisms of virus entry into the human respiratory tract are incompletely characterized. We analyzed publicly available RNA microarray datasets for SARS-CoV-2 entry receptors and cofactors ACE2, TMPRSS2, BSG (CD147) and FURIN. We found that ACE2 and TMPRSS2 are upregulated in the airways of smokers. In asthmatics, ACE2 tended to be downregulated in nasal epithelium, and TMPRSS2 was upregulated in the bronchi. Furthermore, respiratory epithelia were negative for ACE-2 and TMPRSS2 protein expression while positive for BSG and furin, suggesting a possible alternative entry route for SARS-CoV-2.
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spelling pubmed-75232602020-09-29 Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics Matusiak, Magdalena Schürch, Christian M. Respir Res Letter to the Editor SARS-CoV-2 is causing a pandemic with currently > 29 million confirmed cases and > 900,000 deaths worldwide. The locations and mechanisms of virus entry into the human respiratory tract are incompletely characterized. We analyzed publicly available RNA microarray datasets for SARS-CoV-2 entry receptors and cofactors ACE2, TMPRSS2, BSG (CD147) and FURIN. We found that ACE2 and TMPRSS2 are upregulated in the airways of smokers. In asthmatics, ACE2 tended to be downregulated in nasal epithelium, and TMPRSS2 was upregulated in the bronchi. Furthermore, respiratory epithelia were negative for ACE-2 and TMPRSS2 protein expression while positive for BSG and furin, suggesting a possible alternative entry route for SARS-CoV-2. BioMed Central 2020-09-29 2020 /pmc/articles/PMC7523260/ /pubmed/32993656 http://dx.doi.org/10.1186/s12931-020-01521-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Matusiak, Magdalena
Schürch, Christian M.
Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
title Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
title_full Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
title_fullStr Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
title_full_unstemmed Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
title_short Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
title_sort expression of sars-cov-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523260/
https://www.ncbi.nlm.nih.gov/pubmed/32993656
http://dx.doi.org/10.1186/s12931-020-01521-x
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