Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

BACKGROUND: Mitochondrial DNA copy number (mtDNA-CN) has been associated with a variety of aging-related diseases, including all-cause mortality. However, the mechanism by which mtDNA-CN influences disease is not currently understood. One such mechanism may be through regulation of nuclear gene expr...

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Detalles Bibliográficos
Autores principales: Castellani, Christina A., Longchamps, Ryan J., Sumpter, Jason A., Newcomb, Charles E., Lane, John A., Grove, Megan L., Bressler, Jan, Brody, Jennifer A., Floyd, James S., Bartz, Traci M., Taylor, Kent D., Wang, Penglong, Tin, Adrienne, Coresh, Josef, Pankow, James S., Fornage, Myriam, Guallar, Eliseo, O’Rourke, Brian, Pankratz, Nathan, Liu, Chunyu, Levy, Daniel, Sotoodehnia, Nona, Boerwinkle, Eric, Arking, Dan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523322/
https://www.ncbi.nlm.nih.gov/pubmed/32988399
http://dx.doi.org/10.1186/s13073-020-00778-7

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