Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1

BACKGROUND: Immune checkpoint blockade (ICB) therapy has demonstrated considerable clinical benefit in several malignancies, but has shown favorable response in only a small proportion of cancer patients. Recent studies have shown that matrix metalloproteinases (MMPs) are highly associated with the...

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Detalles Bibliográficos
Autores principales: Ye, Youqiong, Kuang, Xinwei, Xie, Zuozhong, Liang, Long, Zhang, Zhao, Zhang, Yongchang, Ma, Fangyu, Gao, Qian, Chang, Ruimin, Lee, Heng-Huan, Zhao, Shuang, Su, Juan, Li, Hui, Peng, Jingbo, Chen, Huifang, Yin, Minzhu, Peng, Cong, Yang, Nong, Wang, Jing, Liu, Jing, Liu, Hong, Han, Leng, Chen, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523356/
https://www.ncbi.nlm.nih.gov/pubmed/32988398
http://dx.doi.org/10.1186/s13073-020-00780-z

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