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CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome
CRISPR-nucleases have been widely applied for editing cellular and viral genomes, but nuclease-mediated genome editing of double-stranded RNA (dsRNA) viruses has not yet been reported. Here, by engineering CRISPR-Csy4 nuclease to localize to rotavirus viral factories, we achieve the nuclease-mediate...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Authors.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523552/ https://www.ncbi.nlm.nih.gov/pubmed/32997981 http://dx.doi.org/10.1016/j.celrep.2020.108205 |