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Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer

Intraductal carcinoma of the prostate (IDC-P) is an aggressive pathological pattern of prostate cancer (PCa). We investigated the association of IDC-P in prostate biopsy (PBx) with several pathological features after radical prostatectomy (RP) and its prognostic value in high-risk PCa. A total of 41...

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Autores principales: Zhu, Sha, Zhao, Jin-Ge, Chen, Jun-Ru, Liu, Zhen-Hua, Sun, Guang-Xi, Wang, Zhi-Peng, Ni, Yu-Chao, Dai, Jin-Dong, Shen, Peng-Fei, Zeng, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523608/
https://www.ncbi.nlm.nih.gov/pubmed/31710002
http://dx.doi.org/10.4103/aja.aja_117_19
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author Zhu, Sha
Zhao, Jin-Ge
Chen, Jun-Ru
Liu, Zhen-Hua
Sun, Guang-Xi
Wang, Zhi-Peng
Ni, Yu-Chao
Dai, Jin-Dong
Shen, Peng-Fei
Zeng, Hao
author_facet Zhu, Sha
Zhao, Jin-Ge
Chen, Jun-Ru
Liu, Zhen-Hua
Sun, Guang-Xi
Wang, Zhi-Peng
Ni, Yu-Chao
Dai, Jin-Dong
Shen, Peng-Fei
Zeng, Hao
author_sort Zhu, Sha
collection PubMed
description Intraductal carcinoma of the prostate (IDC-P) is an aggressive pathological pattern of prostate cancer (PCa). We investigated the association of IDC-P in prostate biopsy (PBx) with several pathological features after radical prostatectomy (RP) and its prognostic value in high-risk PCa. A total of 418 patients with high-risk PCa after RP were included in this study. IDC-P and its architectural patterns were identified according to the 2016 World Health Organization Classification. Chi-squared test and logistic regression were used to investigate the correlation between IDC-P and post-RP pathological features. Kaplan–Meier curves and Cox regression were applied to explore the prognostic value of IDC-P. IDC-P was identified in PBx in 36/418 (8.6%) patients. Logistic regression indicated that IDC-P in PBx was independently associated with several pathological features of RP, including Gleason score 8–10 (P < 0.001), seminal vesicular invasion (P < 0.001), and pathological T (pT) 3a (P = 0.043). Patients with IDC-P in PBx manifested poorer biochemical-free survival (BFS) than those without IDC-P (37.47 months vs not reached, P < 0.001). The addition of IDC-P in several prognostic nomograms could improve the predictive accuracy of these tools. We conclude that IDC-P in PBx is positively associated with several aggressive pathological features after RP in high-risk PCa. In addition, IDC-P in PBx could effectively predict the BFS of high-risk PCa patients after RP.
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spelling pubmed-75236082020-10-09 Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer Zhu, Sha Zhao, Jin-Ge Chen, Jun-Ru Liu, Zhen-Hua Sun, Guang-Xi Wang, Zhi-Peng Ni, Yu-Chao Dai, Jin-Dong Shen, Peng-Fei Zeng, Hao Asian J Androl Original Article Intraductal carcinoma of the prostate (IDC-P) is an aggressive pathological pattern of prostate cancer (PCa). We investigated the association of IDC-P in prostate biopsy (PBx) with several pathological features after radical prostatectomy (RP) and its prognostic value in high-risk PCa. A total of 418 patients with high-risk PCa after RP were included in this study. IDC-P and its architectural patterns were identified according to the 2016 World Health Organization Classification. Chi-squared test and logistic regression were used to investigate the correlation between IDC-P and post-RP pathological features. Kaplan–Meier curves and Cox regression were applied to explore the prognostic value of IDC-P. IDC-P was identified in PBx in 36/418 (8.6%) patients. Logistic regression indicated that IDC-P in PBx was independently associated with several pathological features of RP, including Gleason score 8–10 (P < 0.001), seminal vesicular invasion (P < 0.001), and pathological T (pT) 3a (P = 0.043). Patients with IDC-P in PBx manifested poorer biochemical-free survival (BFS) than those without IDC-P (37.47 months vs not reached, P < 0.001). The addition of IDC-P in several prognostic nomograms could improve the predictive accuracy of these tools. We conclude that IDC-P in PBx is positively associated with several aggressive pathological features after RP in high-risk PCa. In addition, IDC-P in PBx could effectively predict the BFS of high-risk PCa patients after RP. Wolters Kluwer - Medknow 2019-11-08 /pmc/articles/PMC7523608/ /pubmed/31710002 http://dx.doi.org/10.4103/aja.aja_117_19 Text en Copyright: ©The Author(s)(2019) http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Zhu, Sha
Zhao, Jin-Ge
Chen, Jun-Ru
Liu, Zhen-Hua
Sun, Guang-Xi
Wang, Zhi-Peng
Ni, Yu-Chao
Dai, Jin-Dong
Shen, Peng-Fei
Zeng, Hao
Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer
title Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer
title_full Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer
title_fullStr Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer
title_full_unstemmed Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer
title_short Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer
title_sort intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523608/
https://www.ncbi.nlm.nih.gov/pubmed/31710002
http://dx.doi.org/10.4103/aja.aja_117_19
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