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Impairments of auditory scene analysis in posterior cortical atrophy

Although posterior cortical atrophy is often regarded as the canonical ‘visual dementia’, auditory symptoms may also be salient in this disorder. Patients often report particular difficulty hearing in busy environments; however, the core cognitive process—parsing of the auditory environment (‘audito...

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Detalles Bibliográficos
Autores principales: Hardy, Chris J D, Yong, Keir X X, Goll, Johanna C, Crutch, Sebastian J, Warren, Jason D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523698/
https://www.ncbi.nlm.nih.gov/pubmed/32875326
http://dx.doi.org/10.1093/brain/awaa221
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author Hardy, Chris J D
Yong, Keir X X
Goll, Johanna C
Crutch, Sebastian J
Warren, Jason D
author_facet Hardy, Chris J D
Yong, Keir X X
Goll, Johanna C
Crutch, Sebastian J
Warren, Jason D
author_sort Hardy, Chris J D
collection PubMed
description Although posterior cortical atrophy is often regarded as the canonical ‘visual dementia’, auditory symptoms may also be salient in this disorder. Patients often report particular difficulty hearing in busy environments; however, the core cognitive process—parsing of the auditory environment (‘auditory scene analysis’)—has been poorly characterized. In this cross-sectional study, we used customized perceptual tasks to assess two generic cognitive operations underpinning auditory scene analysis—sound source segregation and sound event grouping—in a cohort of 21 patients with posterior cortical atrophy, referenced to 15 healthy age-matched individuals and 21 patients with typical Alzheimer’s disease. After adjusting for peripheral hearing function and performance on control tasks assessing perceptual and executive response demands, patients with posterior cortical atrophy performed significantly worse on both auditory scene analysis tasks relative to healthy controls and patients with typical Alzheimer’s disease (all P < 0.05). Our findings provide further evidence of central auditory dysfunction in posterior cortical atrophy, with implications for our pathophysiological understanding of Alzheimer syndromes as well as clinical diagnosis and management.
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spelling pubmed-75236982020-10-10 Impairments of auditory scene analysis in posterior cortical atrophy Hardy, Chris J D Yong, Keir X X Goll, Johanna C Crutch, Sebastian J Warren, Jason D Brain Reports Although posterior cortical atrophy is often regarded as the canonical ‘visual dementia’, auditory symptoms may also be salient in this disorder. Patients often report particular difficulty hearing in busy environments; however, the core cognitive process—parsing of the auditory environment (‘auditory scene analysis’)—has been poorly characterized. In this cross-sectional study, we used customized perceptual tasks to assess two generic cognitive operations underpinning auditory scene analysis—sound source segregation and sound event grouping—in a cohort of 21 patients with posterior cortical atrophy, referenced to 15 healthy age-matched individuals and 21 patients with typical Alzheimer’s disease. After adjusting for peripheral hearing function and performance on control tasks assessing perceptual and executive response demands, patients with posterior cortical atrophy performed significantly worse on both auditory scene analysis tasks relative to healthy controls and patients with typical Alzheimer’s disease (all P < 0.05). Our findings provide further evidence of central auditory dysfunction in posterior cortical atrophy, with implications for our pathophysiological understanding of Alzheimer syndromes as well as clinical diagnosis and management. Oxford University Press 2020-09-01 /pmc/articles/PMC7523698/ /pubmed/32875326 http://dx.doi.org/10.1093/brain/awaa221 Text en © The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Hardy, Chris J D
Yong, Keir X X
Goll, Johanna C
Crutch, Sebastian J
Warren, Jason D
Impairments of auditory scene analysis in posterior cortical atrophy
title Impairments of auditory scene analysis in posterior cortical atrophy
title_full Impairments of auditory scene analysis in posterior cortical atrophy
title_fullStr Impairments of auditory scene analysis in posterior cortical atrophy
title_full_unstemmed Impairments of auditory scene analysis in posterior cortical atrophy
title_short Impairments of auditory scene analysis in posterior cortical atrophy
title_sort impairments of auditory scene analysis in posterior cortical atrophy
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523698/
https://www.ncbi.nlm.nih.gov/pubmed/32875326
http://dx.doi.org/10.1093/brain/awaa221
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