Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection

Short-chain fatty acids (SCFAs) produced by gastrointestinal microbiota regulate immune responses, but host molecular mechanisms remain unknown. Unbiased screening using SCFA-conjugated affinity nanobeads identified apoptosis-associated speck-like protein (ASC), an adaptor protein of inflammasome co...

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Detalles Bibliográficos
Autores principales: Tsugawa, Hitoshi, Kabe, Yasuaki, Kanai, Ayaka, Sugiura, Yuki, Hida, Shigeaki, Taniguchi, Shun’ichiro, Takahashi, Toshio, Matsui, Hidenori, Yasukawa, Zenta, Itou, Hiroyuki, Takubo, Keiyo, Suzuki, Hidekazu, Honda, Kenya, Handa, Hiroshi, Suematsu, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524008/
https://www.ncbi.nlm.nih.gov/pubmed/32991574
http://dx.doi.org/10.1371/journal.pbio.3000813

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