Cargando…
Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction
AIMS: Heart failure (HF) is a complex clinical syndrome with multiple comorbidities. Cognitive impairment, stress, anxiety, depression, and lower quality of life are prevalent in HF. Herein, we explore the interplay between these parameters and study their value to predict major adverse cardiovascul...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524225/ https://www.ncbi.nlm.nih.gov/pubmed/32822110 http://dx.doi.org/10.1002/ehf2.12932 |
_version_ | 1783588516312121344 |
---|---|
author | Fino, Patrícia Sousa, Rita Matos Carvalho, Renata Sousa, Nuno Almeida, Filipa Pereira, Vítor Hugo |
author_facet | Fino, Patrícia Sousa, Rita Matos Carvalho, Renata Sousa, Nuno Almeida, Filipa Pereira, Vítor Hugo |
author_sort | Fino, Patrícia |
collection | PubMed |
description | AIMS: Heart failure (HF) is a complex clinical syndrome with multiple comorbidities. Cognitive impairment, stress, anxiety, depression, and lower quality of life are prevalent in HF. Herein, we explore the interplay between these parameters and study their value to predict major adverse cardiovascular events (MACEs) and health‐related quality of life (HrQoL) in patients with HF with reduced ejection fraction using guideline recommended assessment tools. METHODS AND RESULTS: We conducted a longitudinal study using a sample of 65 patients from two hospitals. A battery of tests was applied to assess cognition [Montreal Cognitive Assessment (MoCA)], stress (Perceived Stress Scale‐10), anxiety, and depression (Hospital Anxiety and Depression Scale) at baseline. MACEs were registered using clinical records. HrQoL was estimated using the Kansas City Cardiomyopathy Questionnaire (KCCQ). A descriptive statistical analysis was conducted, and multiple linear and Cox regression models conducted to determine the predictive value of neurocognitive parameters and HrQoL in MACE. Both MoCA [hazard ratio = 0.906 (0.829–0.990); P = 0.029] and KCCQ scores were predictors of MACE, but not of overall mortality. Anxiety, depression, and stress scores did not predict MACE. However, anxiety (β = −0.326; P = 0.012) and depression levels (β = −0.309; P = 0.014) were independent predictors of the KCCQ score. CONCLUSIONS: The MoCA score and HrQoL were predictors of MACE‐free survival. Anxiety and depression were good predictors of HrQoL, but not of MACE‐free survival. |
format | Online Article Text |
id | pubmed-7524225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75242252020-10-02 Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction Fino, Patrícia Sousa, Rita Matos Carvalho, Renata Sousa, Nuno Almeida, Filipa Pereira, Vítor Hugo ESC Heart Fail Original Research Articles AIMS: Heart failure (HF) is a complex clinical syndrome with multiple comorbidities. Cognitive impairment, stress, anxiety, depression, and lower quality of life are prevalent in HF. Herein, we explore the interplay between these parameters and study their value to predict major adverse cardiovascular events (MACEs) and health‐related quality of life (HrQoL) in patients with HF with reduced ejection fraction using guideline recommended assessment tools. METHODS AND RESULTS: We conducted a longitudinal study using a sample of 65 patients from two hospitals. A battery of tests was applied to assess cognition [Montreal Cognitive Assessment (MoCA)], stress (Perceived Stress Scale‐10), anxiety, and depression (Hospital Anxiety and Depression Scale) at baseline. MACEs were registered using clinical records. HrQoL was estimated using the Kansas City Cardiomyopathy Questionnaire (KCCQ). A descriptive statistical analysis was conducted, and multiple linear and Cox regression models conducted to determine the predictive value of neurocognitive parameters and HrQoL in MACE. Both MoCA [hazard ratio = 0.906 (0.829–0.990); P = 0.029] and KCCQ scores were predictors of MACE, but not of overall mortality. Anxiety, depression, and stress scores did not predict MACE. However, anxiety (β = −0.326; P = 0.012) and depression levels (β = −0.309; P = 0.014) were independent predictors of the KCCQ score. CONCLUSIONS: The MoCA score and HrQoL were predictors of MACE‐free survival. Anxiety and depression were good predictors of HrQoL, but not of MACE‐free survival. John Wiley and Sons Inc. 2020-08-21 /pmc/articles/PMC7524225/ /pubmed/32822110 http://dx.doi.org/10.1002/ehf2.12932 Text en © 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Articles Fino, Patrícia Sousa, Rita Matos Carvalho, Renata Sousa, Nuno Almeida, Filipa Pereira, Vítor Hugo Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction |
title | Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction |
title_full | Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction |
title_fullStr | Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction |
title_full_unstemmed | Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction |
title_short | Cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction |
title_sort | cognitive performance is associated with worse prognosis in patients with heart failure with reduced ejection fraction |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524225/ https://www.ncbi.nlm.nih.gov/pubmed/32822110 http://dx.doi.org/10.1002/ehf2.12932 |
work_keys_str_mv | AT finopatricia cognitiveperformanceisassociatedwithworseprognosisinpatientswithheartfailurewithreducedejectionfraction AT sousaritamatos cognitiveperformanceisassociatedwithworseprognosisinpatientswithheartfailurewithreducedejectionfraction AT carvalhorenata cognitiveperformanceisassociatedwithworseprognosisinpatientswithheartfailurewithreducedejectionfraction AT sousanuno cognitiveperformanceisassociatedwithworseprognosisinpatientswithheartfailurewithreducedejectionfraction AT almeidafilipa cognitiveperformanceisassociatedwithworseprognosisinpatientswithheartfailurewithreducedejectionfraction AT pereiravitorhugo cognitiveperformanceisassociatedwithworseprognosisinpatientswithheartfailurewithreducedejectionfraction |