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Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants
Infant formula feeding, compared with human milk, has been associated with development of a distinct infant gut microbiome, but no previous study has examined effects of formula with added sugars. This work examined differences in gut microbiota among 91 Hispanic infants who consumed human milk [at...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524300/ https://www.ncbi.nlm.nih.gov/pubmed/32887539 http://dx.doi.org/10.1080/19490976.2020.1813534 |
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author | Jones, Roshonda B. Berger, Paige K. Plows, Jasmine F. Alderete, Tanya L. Millstein, Joshua Fogel, Jennifer Iablokov, Stanislav N. Rodionov, Dmitry A. Osterman, Andrei L. Bode, Lars Goran, Michael I. |
author_facet | Jones, Roshonda B. Berger, Paige K. Plows, Jasmine F. Alderete, Tanya L. Millstein, Joshua Fogel, Jennifer Iablokov, Stanislav N. Rodionov, Dmitry A. Osterman, Andrei L. Bode, Lars Goran, Michael I. |
author_sort | Jones, Roshonda B. |
collection | PubMed |
description | Infant formula feeding, compared with human milk, has been associated with development of a distinct infant gut microbiome, but no previous study has examined effects of formula with added sugars. This work examined differences in gut microbiota among 91 Hispanic infants who consumed human milk [at breast (BB) vs. pumped in bottle (BP)] and 2 kinds of infant formula [(traditional lactose-based (TF) vs. lactose-reduced with added sugar (ASF)]. At 1 and 6 months, infant stool was collected to characterize gut microbiota. At 6 months, mothers completed 24-hour dietary recalls and questionnaires to determine infant consumption of human milk (BB vs. BP) or formula (TF vs. ASF). Linear regression models were used to determine associations of milk consumption type and microbial features at 6 months. Infants in the formula groups exhibited a significantly more ‘mature’ microbiome than infants in the human milk groups with the most pronounced differences observed between the ASF vs. BB groups. In the ASF group, we observed reduced log-normalized abundance of Bifidobacteriaceae (TF-BB Mean Difference = −0.71, ASF-BB Mean Difference = −1.10), and increased abundance of Lachnospiraceae (TF-BB Mean Difference = +0.89, ASF-BB Mean Difference = +1.20). We also observed a higher Community Phenotype Index of propionate, most likely produced by Lachnospiraceae, in the ASF group (TF-BB Mean Difference = +0.27, ASF-BB Mean Difference = +0.36). This study provides the first evidence that consumption of infant formula with added sugar may have a stronger association than birth delivery mode, infant caloric intake, and maternal BMI on the infant’s microbiome at 6 months of age. |
format | Online Article Text |
id | pubmed-7524300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-75243002020-10-06 Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants Jones, Roshonda B. Berger, Paige K. Plows, Jasmine F. Alderete, Tanya L. Millstein, Joshua Fogel, Jennifer Iablokov, Stanislav N. Rodionov, Dmitry A. Osterman, Andrei L. Bode, Lars Goran, Michael I. Gut Microbes Research Article Infant formula feeding, compared with human milk, has been associated with development of a distinct infant gut microbiome, but no previous study has examined effects of formula with added sugars. This work examined differences in gut microbiota among 91 Hispanic infants who consumed human milk [at breast (BB) vs. pumped in bottle (BP)] and 2 kinds of infant formula [(traditional lactose-based (TF) vs. lactose-reduced with added sugar (ASF)]. At 1 and 6 months, infant stool was collected to characterize gut microbiota. At 6 months, mothers completed 24-hour dietary recalls and questionnaires to determine infant consumption of human milk (BB vs. BP) or formula (TF vs. ASF). Linear regression models were used to determine associations of milk consumption type and microbial features at 6 months. Infants in the formula groups exhibited a significantly more ‘mature’ microbiome than infants in the human milk groups with the most pronounced differences observed between the ASF vs. BB groups. In the ASF group, we observed reduced log-normalized abundance of Bifidobacteriaceae (TF-BB Mean Difference = −0.71, ASF-BB Mean Difference = −1.10), and increased abundance of Lachnospiraceae (TF-BB Mean Difference = +0.89, ASF-BB Mean Difference = +1.20). We also observed a higher Community Phenotype Index of propionate, most likely produced by Lachnospiraceae, in the ASF group (TF-BB Mean Difference = +0.27, ASF-BB Mean Difference = +0.36). This study provides the first evidence that consumption of infant formula with added sugar may have a stronger association than birth delivery mode, infant caloric intake, and maternal BMI on the infant’s microbiome at 6 months of age. Taylor & Francis 2020-09-04 /pmc/articles/PMC7524300/ /pubmed/32887539 http://dx.doi.org/10.1080/19490976.2020.1813534 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jones, Roshonda B. Berger, Paige K. Plows, Jasmine F. Alderete, Tanya L. Millstein, Joshua Fogel, Jennifer Iablokov, Stanislav N. Rodionov, Dmitry A. Osterman, Andrei L. Bode, Lars Goran, Michael I. Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants |
title | Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants |
title_full | Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants |
title_fullStr | Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants |
title_full_unstemmed | Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants |
title_short | Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants |
title_sort | lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in hispanic infants |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524300/ https://www.ncbi.nlm.nih.gov/pubmed/32887539 http://dx.doi.org/10.1080/19490976.2020.1813534 |
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