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Can gut microbiota of men who have sex with men influence HIV transmission?
Gaining a complete understanding of transmission risk factors will assist in efforts to reduce new HIV infections, especially within the disproportionally affected population of men who have sex with men (MSM). We recently reported that the fecal microbiota of MSM elevates immune activation in gnoto...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524317/ https://www.ncbi.nlm.nih.gov/pubmed/32036739 http://dx.doi.org/10.1080/19490976.2019.1700756 |
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author | Coleman, Sara L. Neff, C. Preston Li, Sam X. Armstrong, Abigail J.S. Schneider, Jennifer M. Sen, Sharon Fennimore, Blair Campbell, Thomas B. Lozupone, Catherine A. Palmer, Brent E. |
author_facet | Coleman, Sara L. Neff, C. Preston Li, Sam X. Armstrong, Abigail J.S. Schneider, Jennifer M. Sen, Sharon Fennimore, Blair Campbell, Thomas B. Lozupone, Catherine A. Palmer, Brent E. |
author_sort | Coleman, Sara L. |
collection | PubMed |
description | Gaining a complete understanding of transmission risk factors will assist in efforts to reduce new HIV infections, especially within the disproportionally affected population of men who have sex with men (MSM). We recently reported that the fecal microbiota of MSM elevates immune activation in gnotobiotic mice and enhances HIV infection in vitro over that of fecal microbiota from men who have sex with women. We also demonstrated elevation of the gut homing marker CD103 (integrin αE) on CD4(+) T cells by MSM-microbiota. Here we provide additional evidence that the gut microbiota is a risk factor for HIV transmission in MSM by showing elevated frequencies of the HIV co-receptor CCR5 on CD4(+) T cells in human rectosigmoid colon biopsies. We discuss our interest in specific MSM-associated bacteria and propose the influx of CD103(+) and CCR5(+) CD4(+) T cells into the colon as a potential link between the MSM microbiota and HIV transmission. |
format | Online Article Text |
id | pubmed-7524317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-75243172020-10-06 Can gut microbiota of men who have sex with men influence HIV transmission? Coleman, Sara L. Neff, C. Preston Li, Sam X. Armstrong, Abigail J.S. Schneider, Jennifer M. Sen, Sharon Fennimore, Blair Campbell, Thomas B. Lozupone, Catherine A. Palmer, Brent E. Gut Microbes Addendum Gaining a complete understanding of transmission risk factors will assist in efforts to reduce new HIV infections, especially within the disproportionally affected population of men who have sex with men (MSM). We recently reported that the fecal microbiota of MSM elevates immune activation in gnotobiotic mice and enhances HIV infection in vitro over that of fecal microbiota from men who have sex with women. We also demonstrated elevation of the gut homing marker CD103 (integrin αE) on CD4(+) T cells by MSM-microbiota. Here we provide additional evidence that the gut microbiota is a risk factor for HIV transmission in MSM by showing elevated frequencies of the HIV co-receptor CCR5 on CD4(+) T cells in human rectosigmoid colon biopsies. We discuss our interest in specific MSM-associated bacteria and propose the influx of CD103(+) and CCR5(+) CD4(+) T cells into the colon as a potential link between the MSM microbiota and HIV transmission. Taylor & Francis 2020-02-10 /pmc/articles/PMC7524317/ /pubmed/32036739 http://dx.doi.org/10.1080/19490976.2019.1700756 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Addendum Coleman, Sara L. Neff, C. Preston Li, Sam X. Armstrong, Abigail J.S. Schneider, Jennifer M. Sen, Sharon Fennimore, Blair Campbell, Thomas B. Lozupone, Catherine A. Palmer, Brent E. Can gut microbiota of men who have sex with men influence HIV transmission? |
title | Can gut microbiota of men who have sex with men influence HIV transmission? |
title_full | Can gut microbiota of men who have sex with men influence HIV transmission? |
title_fullStr | Can gut microbiota of men who have sex with men influence HIV transmission? |
title_full_unstemmed | Can gut microbiota of men who have sex with men influence HIV transmission? |
title_short | Can gut microbiota of men who have sex with men influence HIV transmission? |
title_sort | can gut microbiota of men who have sex with men influence hiv transmission? |
topic | Addendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524317/ https://www.ncbi.nlm.nih.gov/pubmed/32036739 http://dx.doi.org/10.1080/19490976.2019.1700756 |
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