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Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity
The pathophysiology, immune reaction, and differential vulnerability of different population groups and viral host immune system evasion strategies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not yet well understood. Here, we reviewed the multitude of known strategi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524535/ https://www.ncbi.nlm.nih.gov/pubmed/33015593 http://dx.doi.org/10.1016/j.isci.2020.101631 |
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author | Burtscher, Johannes Cappellano, Giuseppe Omori, Akiko Koshiba, Takumi Millet, Grégoire P. |
author_facet | Burtscher, Johannes Cappellano, Giuseppe Omori, Akiko Koshiba, Takumi Millet, Grégoire P. |
author_sort | Burtscher, Johannes |
collection | PubMed |
description | The pathophysiology, immune reaction, and differential vulnerability of different population groups and viral host immune system evasion strategies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not yet well understood. Here, we reviewed the multitude of known strategies of coronaviruses and other viruses to usurp mitochondria-associated mechanisms involved in the host innate immune response and put them in context with the current knowledge on SARS-CoV-2. We argue that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2. Mitochondrial health thus may determine differential vulnerabilities to SARS-CoV-2 infection rendering markers of mitochondrial functions promising potential biomarkers for SARS-CoV-2 infection risk and severity of outcome. Current knowledge gaps on our understanding of mitochondrial involvement in SARS-CoV-2 infection, lifestyle, and pharmacological strategies to improve mitochondrial integrity and potential reciprocal interactions with chronic and age-related diseases, e.g., Parkinson disease, are pointed out. |
format | Online Article Text |
id | pubmed-7524535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75245352020-09-30 Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity Burtscher, Johannes Cappellano, Giuseppe Omori, Akiko Koshiba, Takumi Millet, Grégoire P. iScience Perspective The pathophysiology, immune reaction, and differential vulnerability of different population groups and viral host immune system evasion strategies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not yet well understood. Here, we reviewed the multitude of known strategies of coronaviruses and other viruses to usurp mitochondria-associated mechanisms involved in the host innate immune response and put them in context with the current knowledge on SARS-CoV-2. We argue that maintenance of mitochondrial integrity is essential for adequate innate immune system responses and to blunt mitochondrial modulation by SARS-CoV-2. Mitochondrial health thus may determine differential vulnerabilities to SARS-CoV-2 infection rendering markers of mitochondrial functions promising potential biomarkers for SARS-CoV-2 infection risk and severity of outcome. Current knowledge gaps on our understanding of mitochondrial involvement in SARS-CoV-2 infection, lifestyle, and pharmacological strategies to improve mitochondrial integrity and potential reciprocal interactions with chronic and age-related diseases, e.g., Parkinson disease, are pointed out. Elsevier 2020-09-29 /pmc/articles/PMC7524535/ /pubmed/33015593 http://dx.doi.org/10.1016/j.isci.2020.101631 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Perspective Burtscher, Johannes Cappellano, Giuseppe Omori, Akiko Koshiba, Takumi Millet, Grégoire P. Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity |
title | Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity |
title_full | Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity |
title_fullStr | Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity |
title_full_unstemmed | Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity |
title_short | Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity |
title_sort | mitochondria: in the cross fire of sars-cov-2 and immunity |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524535/ https://www.ncbi.nlm.nih.gov/pubmed/33015593 http://dx.doi.org/10.1016/j.isci.2020.101631 |
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