Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection

Influenza-specific antibody dependent cellular cytotoxicity (ADCC) antibodies have a broad cross reactivity and potential as an immune correlate for universal vaccines. Peptide-mapping for ADCC reactivity of H1-HA and H7-HA proteins from human serum samples identified high ADCC-inducing peptides in...

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Autores principales: Kavian, Niloufar, Hachim, Asmaa, Poon, Leo L.M., Valkenburg, Sophie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524583/
https://www.ncbi.nlm.nih.gov/pubmed/32718818
http://dx.doi.org/10.1016/j.vaccine.2020.07.008
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author Kavian, Niloufar
Hachim, Asmaa
Poon, Leo L.M.
Valkenburg, Sophie A.
author_facet Kavian, Niloufar
Hachim, Asmaa
Poon, Leo L.M.
Valkenburg, Sophie A.
author_sort Kavian, Niloufar
collection PubMed
description Influenza-specific antibody dependent cellular cytotoxicity (ADCC) antibodies have a broad cross reactivity and potential as an immune correlate for universal vaccines. Peptide-mapping for ADCC reactivity of H1-HA and H7-HA proteins from human serum samples identified high ADCC-inducing peptides in both the HA1 and HA2 regions. Vaccination of mice with single ADCC-peptides induced ADCC activity leading to partial protection from lethal influenza challenge, with increased survival, reduced viral loads, and reduced activation of NK cells in the lungs. Targeted vaccination strategies to elicit ADCC responses may provide an approach for universal vaccines.
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spelling pubmed-75245832020-09-29 Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection Kavian, Niloufar Hachim, Asmaa Poon, Leo L.M. Valkenburg, Sophie A. Vaccine Article Influenza-specific antibody dependent cellular cytotoxicity (ADCC) antibodies have a broad cross reactivity and potential as an immune correlate for universal vaccines. Peptide-mapping for ADCC reactivity of H1-HA and H7-HA proteins from human serum samples identified high ADCC-inducing peptides in both the HA1 and HA2 regions. Vaccination of mice with single ADCC-peptides induced ADCC activity leading to partial protection from lethal influenza challenge, with increased survival, reduced viral loads, and reduced activation of NK cells in the lungs. Targeted vaccination strategies to elicit ADCC responses may provide an approach for universal vaccines. 2020-07-25 2020-08-18 /pmc/articles/PMC7524583/ /pubmed/32718818 http://dx.doi.org/10.1016/j.vaccine.2020.07.008 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kavian, Niloufar
Hachim, Asmaa
Poon, Leo L.M.
Valkenburg, Sophie A.
Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection
title Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection
title_full Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection
title_fullStr Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection
title_full_unstemmed Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection
title_short Vaccination with ADCC activating HA peptide epitopes provides 1 partial protection from influenza infection
title_sort vaccination with adcc activating ha peptide epitopes provides 1 partial protection from influenza infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524583/
https://www.ncbi.nlm.nih.gov/pubmed/32718818
http://dx.doi.org/10.1016/j.vaccine.2020.07.008
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