Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike

SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins of SARS-CoV-2 mediate viral entry and are the main targets for neutralizing antibodies. Understanding the antibody respons...

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Detalles Bibliográficos
Autores principales: Prévost, Jérémie, Gasser, Romain, Beaudoin-Bussières, Guillaume, Richard, Jonathan, Duerr, Ralf, Laumaea, Annemarie, Anand, Sai Priya, Goyette, Guillaume, Benlarbi, Mehdi, Ding, Shilei, Medjahed, Halima, Lewin, Antoine, Perreault, Josée, Tremblay, Tony, Gendron-Lepage, Gabrielle, Gauthier, Nicolas, Carrier, Marc, Marcoux, Diane, Piché, Alain, Lavoie, Myriam, Benoit, Alexandre, Loungnarath, Vilayvong, Brochu, Gino, Haddad, Elie, Stacey, Hannah D., Miller, Matthew S., Desforges, Marc, Talbot, Pierre J., Maule, Graham T. Gould, Côté, Marceline, Therrien, Christian, Serhir, Bouchra, Bazin, Renée, Roger, Michel, Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524645/
https://www.ncbi.nlm.nih.gov/pubmed/33015650
http://dx.doi.org/10.1016/j.xcrm.2020.100126
Descripción
Sumario:SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins of SARS-CoV-2 mediate viral entry and are the main targets for neutralizing antibodies. Understanding the antibody response directed against SARS-CoV-2 is crucial for the development of vaccine, therapeutic, and public health interventions. Here, we perform a cross-sectional study on 106 SARS-CoV-2-infected individuals to evaluate humoral responses against SARS-CoV-2 Spike. Most infected individuals elicit anti-Spike antibodies within 2 weeks of the onset of symptoms. The levels of receptor binding domain (RBD)-specific immunoglobulin G (IgG) persist over time, and the levels of anti-RBD IgM decrease after symptom resolution. Although most individuals develop neutralizing antibodies within 2 weeks of infection, the level of neutralizing activity is significantly decreased over time. Our results highlight the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.

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