Cargando…

Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice

The present study investigated possible therapeutic effects of radiofrequency or hypomagnetic fields on the growth rate of two types of implanted tumours. To this end, mice with implanted fibrosarcoma and pancreatic tumours were exposed continuously to a 2 µT, 10 MHz radiofrequency magnetic field (M...

Descripción completa

Detalles Bibliográficos
Autores principales: Luukkonen, Jukka, Naarala, Jonne, Juutilainen, Jukka, Barnes, Frank, Martino, Carlos F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524722/
https://www.ncbi.nlm.nih.gov/pubmed/32684625
http://dx.doi.org/10.1038/s41416-020-0995-3
_version_ 1783588600745558016
author Luukkonen, Jukka
Naarala, Jonne
Juutilainen, Jukka
Barnes, Frank
Martino, Carlos F.
author_facet Luukkonen, Jukka
Naarala, Jonne
Juutilainen, Jukka
Barnes, Frank
Martino, Carlos F.
author_sort Luukkonen, Jukka
collection PubMed
description The present study investigated possible therapeutic effects of radiofrequency or hypomagnetic fields on the growth rate of two types of implanted tumours. To this end, mice with implanted fibrosarcoma and pancreatic tumours were exposed continuously to a 2 µT, 10 MHz radiofrequency magnetic field (MF) perpendicular to a 45 µT static MF or to a hypomagnetic (~0.4–1 µT) field. The reasoning for a 10 MHz treatment was based on a current theoretical explanation for MF effects, which predicts a resonance phenomenon in this frequency range. Radiofrequency MFs reduced consistently the growth rate of two implanted tumour types (by ~30% in both cases). Also, hypomagnetic field hindered tumour growth in both tumour types, but the observation was not statistically significant with fibrosarcoma tumours. In conclusion, although experiments included a limited number of animals, the results indicate that MFs may offer a novel therapeutic strategy in the treatment of cancer.
format Online
Article
Text
id pubmed-7524722
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-75247222021-07-20 Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice Luukkonen, Jukka Naarala, Jonne Juutilainen, Jukka Barnes, Frank Martino, Carlos F. Br J Cancer Brief Communication The present study investigated possible therapeutic effects of radiofrequency or hypomagnetic fields on the growth rate of two types of implanted tumours. To this end, mice with implanted fibrosarcoma and pancreatic tumours were exposed continuously to a 2 µT, 10 MHz radiofrequency magnetic field (MF) perpendicular to a 45 µT static MF or to a hypomagnetic (~0.4–1 µT) field. The reasoning for a 10 MHz treatment was based on a current theoretical explanation for MF effects, which predicts a resonance phenomenon in this frequency range. Radiofrequency MFs reduced consistently the growth rate of two implanted tumour types (by ~30% in both cases). Also, hypomagnetic field hindered tumour growth in both tumour types, but the observation was not statistically significant with fibrosarcoma tumours. In conclusion, although experiments included a limited number of animals, the results indicate that MFs may offer a novel therapeutic strategy in the treatment of cancer. Nature Publishing Group UK 2020-07-20 2020-09-29 /pmc/articles/PMC7524722/ /pubmed/32684625 http://dx.doi.org/10.1038/s41416-020-0995-3 Text en © Cancer Research UK 2020 https://creativecommons.org/licenses/by/4.0/Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Brief Communication
Luukkonen, Jukka
Naarala, Jonne
Juutilainen, Jukka
Barnes, Frank
Martino, Carlos F.
Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
title Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
title_full Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
title_fullStr Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
title_full_unstemmed Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
title_short Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
title_sort pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524722/
https://www.ncbi.nlm.nih.gov/pubmed/32684625
http://dx.doi.org/10.1038/s41416-020-0995-3
work_keys_str_mv AT luukkonenjukka pilotstudyonthetherapeuticpotentialofradiofrequencymagneticfieldsgrowthinhibitionofimplantedtumoursinmice
AT naaralajonne pilotstudyonthetherapeuticpotentialofradiofrequencymagneticfieldsgrowthinhibitionofimplantedtumoursinmice
AT juutilainenjukka pilotstudyonthetherapeuticpotentialofradiofrequencymagneticfieldsgrowthinhibitionofimplantedtumoursinmice
AT barnesfrank pilotstudyonthetherapeuticpotentialofradiofrequencymagneticfieldsgrowthinhibitionofimplantedtumoursinmice
AT martinocarlosf pilotstudyonthetherapeuticpotentialofradiofrequencymagneticfieldsgrowthinhibitionofimplantedtumoursinmice