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A defined N6-methyladenosine (m(6)A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions

Muscle-specific adult stem cells (MuSCs) are required for skeletal muscle regeneration. To ensure efficient skeletal muscle regeneration after injury, MuSCs must undergo state transitions as they are activated from quiescence, give rise to a population of proliferating myoblasts, and continue either...

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Detalles Bibliográficos
Autores principales: Gheller, Brandon J., Blum, Jamie E., Fong, Ern Hwei Hannah, Malysheva, Olga V., Cosgrove, Benjamin D., Thalacker-Mercer, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524727/
https://www.ncbi.nlm.nih.gov/pubmed/33083017
http://dx.doi.org/10.1038/s41420-020-00328-5