Differential Effects of Sacubitril/Valsartan on Diastolic Function in Mice With Obesity-Related Metabolic Heart Disease

Mice with obesity and metabolic heart disease (MHD) due to a high-fat, high-sucrose diet were treated with placebo, a clinically relevant dose of sacubitril (SAC)/valsartan (VAL), or an equivalent dose of VAL for 4 months. There were striking differences between SAC/VAL and VAL with regard to: 1) di...

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Detalles Bibliográficos
Autores principales: Croteau, Dominique, Qin, Fuzhong, Chambers, Jordan M., Kallick, Ethan, Luptak, Ivan, Panagia, Marcello, Pimentel, David R., Siwik, Deborah A., Colucci, Wilson S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524781/
https://www.ncbi.nlm.nih.gov/pubmed/33015414
http://dx.doi.org/10.1016/j.jacbts.2020.07.006

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