The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure

Contradictory findings of estrogen supplementation in cardiac disease highlight the need to investigate the involvement of estrogen in the progression of heart failure in an animal model that lacks traditional comorbidities. Heart failure was induced by aortic constriction (AC) in female guinea pigs...

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Autores principales: Firth, Jahn M., Yang, Hsiang-Yu, Francis, Alice J., Islam, Najah, MacLeod, Kenneth T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524784/
https://www.ncbi.nlm.nih.gov/pubmed/33015413
http://dx.doi.org/10.1016/j.jacbts.2020.06.013
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author Firth, Jahn M.
Yang, Hsiang-Yu
Francis, Alice J.
Islam, Najah
MacLeod, Kenneth T.
author_facet Firth, Jahn M.
Yang, Hsiang-Yu
Francis, Alice J.
Islam, Najah
MacLeod, Kenneth T.
author_sort Firth, Jahn M.
collection PubMed
description Contradictory findings of estrogen supplementation in cardiac disease highlight the need to investigate the involvement of estrogen in the progression of heart failure in an animal model that lacks traditional comorbidities. Heart failure was induced by aortic constriction (AC) in female guinea pigs. Selected AC animals were ovariectomized (ACOV), and a group of these received 17β-estradiol supplementation (ACOV+E). One hundred-fifty days post-AC surgery, left-ventricular myocytes were isolated, and their electrophysiology and Ca(2+) and Na(+) regulation were examined. Long-term absence of ovarian hormones exacerbates the decline in cardiac function during the progression to heart failure. Estrogen supplementation reverses these aggravating effects.
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spelling pubmed-75247842020-10-02 The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure Firth, Jahn M. Yang, Hsiang-Yu Francis, Alice J. Islam, Najah MacLeod, Kenneth T. JACC Basic Transl Sci Preclinical Research Contradictory findings of estrogen supplementation in cardiac disease highlight the need to investigate the involvement of estrogen in the progression of heart failure in an animal model that lacks traditional comorbidities. Heart failure was induced by aortic constriction (AC) in female guinea pigs. Selected AC animals were ovariectomized (ACOV), and a group of these received 17β-estradiol supplementation (ACOV+E). One hundred-fifty days post-AC surgery, left-ventricular myocytes were isolated, and their electrophysiology and Ca(2+) and Na(+) regulation were examined. Long-term absence of ovarian hormones exacerbates the decline in cardiac function during the progression to heart failure. Estrogen supplementation reverses these aggravating effects. Elsevier 2020-09-02 /pmc/articles/PMC7524784/ /pubmed/33015413 http://dx.doi.org/10.1016/j.jacbts.2020.06.013 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preclinical Research
Firth, Jahn M.
Yang, Hsiang-Yu
Francis, Alice J.
Islam, Najah
MacLeod, Kenneth T.
The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure
title The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure
title_full The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure
title_fullStr The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure
title_full_unstemmed The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure
title_short The Effect of Estrogen on Intracellular Ca(2+) and Na(+) Regulation in Heart Failure
title_sort effect of estrogen on intracellular ca(2+) and na(+) regulation in heart failure
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524784/
https://www.ncbi.nlm.nih.gov/pubmed/33015413
http://dx.doi.org/10.1016/j.jacbts.2020.06.013
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