Cargando…

Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells

2D and 3D cultures of 3T3-L1 cells were employed in a study of the effects of Omidenepag (OMD), interacting with a non-prostanoid EP2 receptor, on adipogenesis. Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes (Pparγ, CEBPa, Ap2, and Glut4) and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ida, Yosuke, Hikage, Fumihito, Umetsu, Araya, Ida, Haruka, Ohguro, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524797/ https://www.ncbi.nlm.nih.gov/pubmed/32994409 http://dx.doi.org/10.1038/s41598-020-72538-x

Ejemplares similares

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts
por: Hikage, Fumihito, et al.
Publicado: (2021)

Reactivities of a Prostanoid EP2 Agonist, Omidenepag, Are Useful for Distinguishing between 3D Spheroids of Human Orbital Fibroblasts without or with Graves’ Orbitopathy
por: Ida, Yosuke, et al.
Publicado: (2021)

Prostaglandin F2 and EP2 Agonists Exert Different Effects on 3D 3T3-L1 Spheroids during Their Culture Phase
por: Ida, Yosuke, et al.
Publicado: (2021)

Comparison of the Drug-Induced Efficacies between Omidenepag Isopropyl, an EP2 Agonist and PGF2α toward TGF-β2-Modulated Human Trabecular Meshwork (HTM) Cells
por: Suzuki, Soma, et al.
Publicado: (2022)

Simultaneous Use of ROCK Inhibitors and EP2 Agonists Induces Unexpected Effects on Adipogenesis and the Physical Properties of 3T3-L1 Preadipocytes
por: Ida, Yosuke, et al.
Publicado: (2021)

ROCK inhibitors enhance the production of large lipid-enriched 3D organoids of 3T3-L1 cells
por: Ida, Yosuke, et al.
Publicado: (2021)

Prostaglandin F2α agonist-induced suppression of 3T3-L1 cell adipogenesis affects spatial formation of extra-cellular matrix
por: Ida, Yosuke, et al.
Publicado: (2020)

Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts
por: Itoh, Kaku, et al.
Publicado: (2020)

STAT3 Is the Master Regulator for the Forming of 3D Spheroids of 3T3-L1 Preadipocytes
por: Ohguro, Hiroshi, et al.
Publicado: (2022)

Addition of ROCK Inhibitors Alleviates Prostaglandin-Induced Inhibition of Adipogenesis in 3T3L-1 Spheroids
por: Ida, Yosuke, et al.
Publicado: (2022)

Brimonidine Modulates the ROCK1 Signaling Effects on Adipogenic Differentiation in 2D and 3D 3T3-L1 Cells
por: Umetsu, Araya, et al.
Publicado: (2022)

3D culture induction of adipogenic differentiation in 3T3-L1 preadipocytes exhibits adipocyte-specific molecular expression patterns and metabolic functions
por: Endo, Keisuke, et al.
Publicado: (2023)

ROCK inhibitors modulate the physical properties and adipogenesis of 3D spheroids of human orbital fibroblasts in different manners
por: Hikage, Fumihito, et al.
Publicado: (2021)

Screening of the Drug-Induced Effects of Prostaglandin EP2 and FP Agonists on 3D Cultures of Dexamethasone-Treated Human Trabecular Meshwork Cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

ROCK inhibitors beneficially alter the spatial configuration of TGFβ2-treated 3D organoids from a human trabecular meshwork (HTM)
por: Ota, Chiaki, et al.
Publicado: (2020)

Modulation of the Physical Properties of 3D Spheroids Derived from Human Scleral Stroma Fibroblasts (HSSFs) with Different Axial Lengths Obtained from Surgical Patients
por: Katayama, Hiroyasu, et al.
Publicado: (2021)

ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners
por: Ida, Yosuke, et al.
Publicado: (2022)

Prostaglandin F2α agonists induced enhancement in collagen1 expression is involved in the pathogenesis of the deepening of upper eyelid sulcus
por: Itoh, Kaku, et al.
Publicado: (2021)

An α2-Adrenergic Agonist, Brimonidine, Beneficially Affects the TGF-β2-Treated Cellular Properties in an In Vitro Culture Model
por: Watanabe, Megumi, et al.
Publicado: (2022)

All Trans-Retinoic Acids Facilitate the Remodeling of 2D and 3D Cultured Human Conjunctival Fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

Hypoxia Differently Affects TGF-β2-Induced Epithelial Mesenchymal Transitions in the 2D and 3D Culture of the Human Retinal Pigment Epithelium Cells
por: Suzuki, Soma, et al.
Publicado: (2022)

All-trans Retinoic Acids Synergistically and Beneficially Affect In Vitro Glaucomatous Trabecular Meshwork (TM) Models Using 2D and 3D Cell Cultures of Human TM Cells
por: Watanabe, Megumi, et al.
Publicado: (2022)

Effects of the Selective EP2 Receptor Agonist Omidenepag on Adipocyte Differentiation in 3T3-L1 Cells
por: Yamamoto, Yasuko, et al.
Publicado: (2020)

Benzalkonium Chloride, Even at Low Concentrations, Deteriorates Intracellular Metabolic Capacity in Human Conjunctival Fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner
por: Ida, Yosuke, et al.
Publicado: (2022)

Establishment of appropriate glaucoma models using dexamethasone or TGFβ2 treated three-dimension (3D) cultured human trabecular meshwork (HTM) cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

Diverse effects of pan-ROCK and ROCK2 inhibitors on 2 D and 3D cultured human trabecular meshwork (HTM) cells treated with TGFβ2
por: Watanabe, Megumi, et al.
Publicado: (2021)

Human Trabecular Meshwork (HTM) Cells Treated with TGF-β2 or Dexamethasone Respond to Compression Stress in Different Manners
por: Watanabe, Megumi, et al.
Publicado: (2022)

FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

Autotaxin May Have Lysophosphatidic Acid-Unrelated Effects on Three-Dimension (3D) Cultured Human Trabecular Meshwork (HTM) Cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners
por: Watanabe, Megumi, et al.
Publicado: (2021)

Unexpected Crosslinking Effects of a Human Thyroid Stimulating Monoclonal Autoantibody, M22, with IGF1 on Adipogenesis in 3T3L-1 Cells
por: Umetsu, Araya, et al.
Publicado: (2023)

Fatty Acid-Binding Proteins 4 and 5 Are Involved in the Pathogenesis of Retinal Vascular Diseases in Different Manners
por: Higashide, Megumi, et al.
Publicado: (2022)

Rosiglitasone and ROCK Inhibitors Modulate Fibrogenetic Changes in TGF-β2 Treated Human Conjunctival Fibroblasts (HconF) in Different Manners
por: Oouchi, Yuika, et al.
Publicado: (2021)

TGF-β2 Induces Epithelial–Mesenchymal Transitions in 2D Planer and 3D Spheroids of the Human Corneal Stroma Fibroblasts in Different Manners
por: Umetsu, Araya, et al.
Publicado: (2023)

Pharmacokinetics, Safety, and Intraocular Pressure-Lowering Profile of Omidenepag Isopropyl, a Selective, Nonprostaglandin, Prostanoid EP2 Receptor Agonist, in Healthy Japanese and Caucasian Volunteers (Phase I Study)
por: Aihara, Makoto, et al.
Publicado: (2019)

G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells
por: Ichioka, Hanae, et al.
Publicado: (2023)

The Antiglaucoma Agent and EP2 Receptor Agonist Omidenepag Does Not Affect Eyelash Growth in Mice
por: Esaki, Yoshihiko, et al.
Publicado: (2020)

Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy
por: Itoh, Kaku, et al.
Publicado: (2021)

Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion
por: Hikage, Fumihito, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7hogof8114r650k2dvoupbuufc