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Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases

BACKGROUND: Barrett's esophagus (BE) is characterized by presence of columnar epithelium in the lower esophageal mucosa, which originally comprises stratified squamous epithelium. Gastroesophageal reflux disease causes BE and BE adenocarcinoma (BEAC); further, the incidence of BEAC is increasin...

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Autores principales: Kuwayama, Naoki, Hoshino, Isamu, Gunji, Hisashi, Tonooka, Toru, Soda, Hiroaki, Eto, Ryotaro, Takiguchi, Nobuhiro, Nabeya, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524988/
https://www.ncbi.nlm.nih.gov/pubmed/32990834
http://dx.doi.org/10.1186/s40792-020-00995-7
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author Kuwayama, Naoki
Hoshino, Isamu
Gunji, Hisashi
Tonooka, Toru
Soda, Hiroaki
Eto, Ryotaro
Takiguchi, Nobuhiro
Nabeya, Yoshihiro
author_facet Kuwayama, Naoki
Hoshino, Isamu
Gunji, Hisashi
Tonooka, Toru
Soda, Hiroaki
Eto, Ryotaro
Takiguchi, Nobuhiro
Nabeya, Yoshihiro
author_sort Kuwayama, Naoki
collection PubMed
description BACKGROUND: Barrett's esophagus (BE) is characterized by presence of columnar epithelium in the lower esophageal mucosa, which originally comprises stratified squamous epithelium. Gastroesophageal reflux disease causes BE and BE adenocarcinoma (BEAC); further, the incidence of BEAC is increasing, especially in developed countries. Long-segment BE (LSBE) has a particularly high carcinogenic potential and necessitates treatment, surveillance, and prevention. CASE PRESENTATION: Herein, we report three cases of BEAC originating from LSBE larger than 15 cm. All three patients underwent surgery for the diagnosis of BEAC. A 66-year-old man with advanced esophageal cancer underwent neoadjuvant chemotherapy and subsequent subtotal esophagectomy. The postoperative pathological diagnosis was of poorly differentiated adenocarcinoma with lymph node metastasis (pT3 pN3 pM0 pStage III based on the Union for International Cancer Control TNM Classification 8th edition). Two years after the operation, the patient was diagnosed with recurrence around the celiac artery and underwent chemotherapy. An 83-year-old woman with advanced esophageal cancer underwent subtotal esophagectomy. The postoperative pathological diagnosis was of well-differentiated adenocarcinoma with supraclavicular lymph node metastasis (pT3 pN3 pM1 pStage IV). Two months after the operation, the patient was diagnosed with recurrence in the neck lymph nodes and underwent chemotherapy; however, she died. A 66-year-old man with early-stage esophageal cancer underwent subtotal esophagectomy. A superficial early cancerous lesion was seen over BE. The postoperative pathological diagnosis was of well-differentiated adenocarcinoma without lymph node metastasis (pT1a pN0 pM0 pStage 0). The patient was found to be alive and recurrence-free 3 months after the operation. CONCLUSIONS: BEAC might show good prognosis if detected and treated early. Extremely LSBE is associated with a high incidence of BEAC; therefore, early detection and treatment with close surveillance is essential.
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spelling pubmed-75249882020-10-14 Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases Kuwayama, Naoki Hoshino, Isamu Gunji, Hisashi Tonooka, Toru Soda, Hiroaki Eto, Ryotaro Takiguchi, Nobuhiro Nabeya, Yoshihiro Surg Case Rep Case Report BACKGROUND: Barrett's esophagus (BE) is characterized by presence of columnar epithelium in the lower esophageal mucosa, which originally comprises stratified squamous epithelium. Gastroesophageal reflux disease causes BE and BE adenocarcinoma (BEAC); further, the incidence of BEAC is increasing, especially in developed countries. Long-segment BE (LSBE) has a particularly high carcinogenic potential and necessitates treatment, surveillance, and prevention. CASE PRESENTATION: Herein, we report three cases of BEAC originating from LSBE larger than 15 cm. All three patients underwent surgery for the diagnosis of BEAC. A 66-year-old man with advanced esophageal cancer underwent neoadjuvant chemotherapy and subsequent subtotal esophagectomy. The postoperative pathological diagnosis was of poorly differentiated adenocarcinoma with lymph node metastasis (pT3 pN3 pM0 pStage III based on the Union for International Cancer Control TNM Classification 8th edition). Two years after the operation, the patient was diagnosed with recurrence around the celiac artery and underwent chemotherapy. An 83-year-old woman with advanced esophageal cancer underwent subtotal esophagectomy. The postoperative pathological diagnosis was of well-differentiated adenocarcinoma with supraclavicular lymph node metastasis (pT3 pN3 pM1 pStage IV). Two months after the operation, the patient was diagnosed with recurrence in the neck lymph nodes and underwent chemotherapy; however, she died. A 66-year-old man with early-stage esophageal cancer underwent subtotal esophagectomy. A superficial early cancerous lesion was seen over BE. The postoperative pathological diagnosis was of well-differentiated adenocarcinoma without lymph node metastasis (pT1a pN0 pM0 pStage 0). The patient was found to be alive and recurrence-free 3 months after the operation. CONCLUSIONS: BEAC might show good prognosis if detected and treated early. Extremely LSBE is associated with a high incidence of BEAC; therefore, early detection and treatment with close surveillance is essential. Springer Berlin Heidelberg 2020-09-29 /pmc/articles/PMC7524988/ /pubmed/32990834 http://dx.doi.org/10.1186/s40792-020-00995-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Kuwayama, Naoki
Hoshino, Isamu
Gunji, Hisashi
Tonooka, Toru
Soda, Hiroaki
Eto, Ryotaro
Takiguchi, Nobuhiro
Nabeya, Yoshihiro
Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases
title Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases
title_full Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases
title_fullStr Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases
title_full_unstemmed Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases
title_short Adenocarcinoma originating from long-segment Barrett's esophagus over 15 cm: a series of 3 cases
title_sort adenocarcinoma originating from long-segment barrett's esophagus over 15 cm: a series of 3 cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524988/
https://www.ncbi.nlm.nih.gov/pubmed/32990834
http://dx.doi.org/10.1186/s40792-020-00995-7
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