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Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus

INTRODUCTION: Subjective tinnitus that is influenced by the somatosensory system is called somatosensory tinnitus (ST). When ST is related to the temporomandibular area, multidisciplinary orofacial treatment can reduce tinnitus severity. It is, however, unknown if we can predict this positive outcom...

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Autores principales: van der Wal, Annemarie, Van de Heyning, Paul, Gilles, Annick, Jacquemin, Laure, Topsakal, Vedat, Van Rompaey, Vincent, Braem, Marc, Visscher, Corine Mirjam, Truijen, Steven, Michiels, Sarah, De Hertogh, Willem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525007/
https://www.ncbi.nlm.nih.gov/pubmed/33041758
http://dx.doi.org/10.3389/fnins.2020.561038
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author van der Wal, Annemarie
Van de Heyning, Paul
Gilles, Annick
Jacquemin, Laure
Topsakal, Vedat
Van Rompaey, Vincent
Braem, Marc
Visscher, Corine Mirjam
Truijen, Steven
Michiels, Sarah
De Hertogh, Willem
author_facet van der Wal, Annemarie
Van de Heyning, Paul
Gilles, Annick
Jacquemin, Laure
Topsakal, Vedat
Van Rompaey, Vincent
Braem, Marc
Visscher, Corine Mirjam
Truijen, Steven
Michiels, Sarah
De Hertogh, Willem
author_sort van der Wal, Annemarie
collection PubMed
description INTRODUCTION: Subjective tinnitus that is influenced by the somatosensory system is called somatosensory tinnitus (ST). When ST is related to the temporomandibular area, multidisciplinary orofacial treatment can reduce tinnitus severity. It is, however, unknown if we can predict this positive outcome. The aim of this study is to look for prognostic indicators that can predict a positive outcome after multidisciplinary orofacial treatment in patients with ST. METHODS: Patients were included when they were diagnosed with temporomandibular-related ST and received a maximum of 18 sessions of orofacial treatment during a 9-week program. Predictors for positive treatment outcome were identified using univariate and multiple logistic regression analyses with the Tinnitus Questionnaire (TQ) and the Tinnitus Functional Index (TFI) as dependent variables. RESULTS: The results of 101 patients were included in the analysis. Immediately after multidisciplinary orofacial treatment, a clinically relevant decrease in TQ score was significantly associated with “shorter duration of tinnitus” [odds ratio (OR) 0.99], “higher initial score on the TQ somatic subscale” (OR 1.52), and “painful palpation of the temporomandibular joint (TMJ)” (OR 2.46). After 9 weeks of follow-up, the “higher initial score on the TQ somatic subscale” remained as the sole predictor (OR 1.44). A clinically relevant decrease on TFI after 9 weeks of follow-up was predicted by “female gender” (OR 2.70), “younger age” (OR 0.96), “shorter duration of the tinnitus” (OR 0.99), “lower pressure pain thresholds (PPT) on TMJ” (OR 0.99), “lower PPT on sternocleidomastoid origin” (OR 0.99), and “better speech in noise perception” (OR 0.88). A multivariate model comprising “shorter duration of tinnitus” and “higher initial score on the somatic subscale of the TQ” correctly predicts the clinically relevant decrease in TQ score after treatment in 68.5%. A second multivariate model comprising “female gender,” “younger age,” and “shorter duration of the tinnitus” correctly predicts a clinically significant decrease on TFI after follow-up in 68.1%. CONCLUSION: We were able to identify various prognostic indicators. “Younger female patients” with a “shorter duration of tinnitus” and a “higher initial score on the TQ somatic subscale” appear to have the best prognosis after multimodal orofacial therapy.
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spelling pubmed-75250072020-10-09 Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus van der Wal, Annemarie Van de Heyning, Paul Gilles, Annick Jacquemin, Laure Topsakal, Vedat Van Rompaey, Vincent Braem, Marc Visscher, Corine Mirjam Truijen, Steven Michiels, Sarah De Hertogh, Willem Front Neurosci Neuroscience INTRODUCTION: Subjective tinnitus that is influenced by the somatosensory system is called somatosensory tinnitus (ST). When ST is related to the temporomandibular area, multidisciplinary orofacial treatment can reduce tinnitus severity. It is, however, unknown if we can predict this positive outcome. The aim of this study is to look for prognostic indicators that can predict a positive outcome after multidisciplinary orofacial treatment in patients with ST. METHODS: Patients were included when they were diagnosed with temporomandibular-related ST and received a maximum of 18 sessions of orofacial treatment during a 9-week program. Predictors for positive treatment outcome were identified using univariate and multiple logistic regression analyses with the Tinnitus Questionnaire (TQ) and the Tinnitus Functional Index (TFI) as dependent variables. RESULTS: The results of 101 patients were included in the analysis. Immediately after multidisciplinary orofacial treatment, a clinically relevant decrease in TQ score was significantly associated with “shorter duration of tinnitus” [odds ratio (OR) 0.99], “higher initial score on the TQ somatic subscale” (OR 1.52), and “painful palpation of the temporomandibular joint (TMJ)” (OR 2.46). After 9 weeks of follow-up, the “higher initial score on the TQ somatic subscale” remained as the sole predictor (OR 1.44). A clinically relevant decrease on TFI after 9 weeks of follow-up was predicted by “female gender” (OR 2.70), “younger age” (OR 0.96), “shorter duration of the tinnitus” (OR 0.99), “lower pressure pain thresholds (PPT) on TMJ” (OR 0.99), “lower PPT on sternocleidomastoid origin” (OR 0.99), and “better speech in noise perception” (OR 0.88). A multivariate model comprising “shorter duration of tinnitus” and “higher initial score on the somatic subscale of the TQ” correctly predicts the clinically relevant decrease in TQ score after treatment in 68.5%. A second multivariate model comprising “female gender,” “younger age,” and “shorter duration of the tinnitus” correctly predicts a clinically significant decrease on TFI after follow-up in 68.1%. CONCLUSION: We were able to identify various prognostic indicators. “Younger female patients” with a “shorter duration of tinnitus” and a “higher initial score on the TQ somatic subscale” appear to have the best prognosis after multimodal orofacial therapy. Frontiers Media S.A. 2020-09-16 /pmc/articles/PMC7525007/ /pubmed/33041758 http://dx.doi.org/10.3389/fnins.2020.561038 Text en Copyright © 2020 van der Wal, Van de Heyning, Gilles, Jacquemin, Topsakal, Van Rompaey, Braem, Visscher, Truijen, Michiels and De Hertogh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
van der Wal, Annemarie
Van de Heyning, Paul
Gilles, Annick
Jacquemin, Laure
Topsakal, Vedat
Van Rompaey, Vincent
Braem, Marc
Visscher, Corine Mirjam
Truijen, Steven
Michiels, Sarah
De Hertogh, Willem
Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus
title Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus
title_full Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus
title_fullStr Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus
title_full_unstemmed Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus
title_short Prognostic Indicators for Positive Treatment Outcome After Multidisciplinary Orofacial Treatment in Patients With Somatosensory Tinnitus
title_sort prognostic indicators for positive treatment outcome after multidisciplinary orofacial treatment in patients with somatosensory tinnitus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525007/
https://www.ncbi.nlm.nih.gov/pubmed/33041758
http://dx.doi.org/10.3389/fnins.2020.561038
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