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Sex-Specific Cognitive Deficits Following Space Radiation Exposure
The radiation fields in space define tangible risks to the health of astronauts, and significant work in rodent models has clearly shown a variety of exposure paradigms to compromise central nervous system (CNS) functionality. Despite our current knowledge, sex differences regarding the risks of spa...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525092/ https://www.ncbi.nlm.nih.gov/pubmed/33192361 http://dx.doi.org/10.3389/fnbeh.2020.535885 |
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author | Parihar, Vipan K. Angulo, Maria C. Allen, Barrett D. Syage, Amber Usmani, Manal T. Passerat de la Chapelle, Estrella Amin, Amal Nayan Flores, Lidia Lin, Xiaomeng Giedzinski, Erich Limoli, Charles L. |
author_facet | Parihar, Vipan K. Angulo, Maria C. Allen, Barrett D. Syage, Amber Usmani, Manal T. Passerat de la Chapelle, Estrella Amin, Amal Nayan Flores, Lidia Lin, Xiaomeng Giedzinski, Erich Limoli, Charles L. |
author_sort | Parihar, Vipan K. |
collection | PubMed |
description | The radiation fields in space define tangible risks to the health of astronauts, and significant work in rodent models has clearly shown a variety of exposure paradigms to compromise central nervous system (CNS) functionality. Despite our current knowledge, sex differences regarding the risks of space radiation exposure on cognitive function remain poorly understood, which is potentially problematic given that 30% of astronauts are women. While work from us and others have demonstrated pronounced cognitive decrements in male mice exposed to charged particle irradiation, here we show that female mice exhibit significant resistance to adverse neurocognitive effects of space radiation. The present findings indicate that male mice exposed to low doses (≤30 cGy) of energetic (400 MeV/n) helium ions ((4)He) show significantly higher levels of neuroinflammation and more extensive cognitive deficits than females. Twelve weeks following (4)He ion exposure, irradiated male mice demonstrated significant deficits in object and place recognition memory accompanied by activation of microglia, marked upregulation of hippocampal Toll-like receptor 4 (TLR4), and increased expression of the pro-inflammatory marker high mobility group box 1 protein (HMGB1). Additionally, we determined that exposure to (4)He ions caused a significant decline in the number of dendritic branch points and total dendritic length along with the hippocampus neurons in female mice. Interestingly, only male mice showed a significant decline of dendritic spine density following irradiation. These data indicate that fundamental differences in inflammatory cascades between male and female mice may drive divergent CNS radiation responses that differentially impact the structural plasticity of neurons and neurocognitive outcomes following cosmic radiation exposure. |
format | Online Article Text |
id | pubmed-7525092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75250922020-11-13 Sex-Specific Cognitive Deficits Following Space Radiation Exposure Parihar, Vipan K. Angulo, Maria C. Allen, Barrett D. Syage, Amber Usmani, Manal T. Passerat de la Chapelle, Estrella Amin, Amal Nayan Flores, Lidia Lin, Xiaomeng Giedzinski, Erich Limoli, Charles L. Front Behav Neurosci Behavioral Neuroscience The radiation fields in space define tangible risks to the health of astronauts, and significant work in rodent models has clearly shown a variety of exposure paradigms to compromise central nervous system (CNS) functionality. Despite our current knowledge, sex differences regarding the risks of space radiation exposure on cognitive function remain poorly understood, which is potentially problematic given that 30% of astronauts are women. While work from us and others have demonstrated pronounced cognitive decrements in male mice exposed to charged particle irradiation, here we show that female mice exhibit significant resistance to adverse neurocognitive effects of space radiation. The present findings indicate that male mice exposed to low doses (≤30 cGy) of energetic (400 MeV/n) helium ions ((4)He) show significantly higher levels of neuroinflammation and more extensive cognitive deficits than females. Twelve weeks following (4)He ion exposure, irradiated male mice demonstrated significant deficits in object and place recognition memory accompanied by activation of microglia, marked upregulation of hippocampal Toll-like receptor 4 (TLR4), and increased expression of the pro-inflammatory marker high mobility group box 1 protein (HMGB1). Additionally, we determined that exposure to (4)He ions caused a significant decline in the number of dendritic branch points and total dendritic length along with the hippocampus neurons in female mice. Interestingly, only male mice showed a significant decline of dendritic spine density following irradiation. These data indicate that fundamental differences in inflammatory cascades between male and female mice may drive divergent CNS radiation responses that differentially impact the structural plasticity of neurons and neurocognitive outcomes following cosmic radiation exposure. Frontiers Media S.A. 2020-09-16 /pmc/articles/PMC7525092/ /pubmed/33192361 http://dx.doi.org/10.3389/fnbeh.2020.535885 Text en Copyright © 2020 Parihar, Angulo, Allen, Syage, Usmani, Passerat de la Chapelle, Amin, Flores, Lin, Giedzinski and Limoli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Parihar, Vipan K. Angulo, Maria C. Allen, Barrett D. Syage, Amber Usmani, Manal T. Passerat de la Chapelle, Estrella Amin, Amal Nayan Flores, Lidia Lin, Xiaomeng Giedzinski, Erich Limoli, Charles L. Sex-Specific Cognitive Deficits Following Space Radiation Exposure |
title | Sex-Specific Cognitive Deficits Following Space Radiation Exposure |
title_full | Sex-Specific Cognitive Deficits Following Space Radiation Exposure |
title_fullStr | Sex-Specific Cognitive Deficits Following Space Radiation Exposure |
title_full_unstemmed | Sex-Specific Cognitive Deficits Following Space Radiation Exposure |
title_short | Sex-Specific Cognitive Deficits Following Space Radiation Exposure |
title_sort | sex-specific cognitive deficits following space radiation exposure |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525092/ https://www.ncbi.nlm.nih.gov/pubmed/33192361 http://dx.doi.org/10.3389/fnbeh.2020.535885 |
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