Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors

Dequalinium is used as an antimicrobial compound for oral health and other microbial infections. Derivatives of dequalinium, the bis-quinolinium cyclophanes UCL 1684 and UCL 1848, are high affinity SK potassium channel antagonists. Here we investigated these compounds as M3 muscarinic receptor (mACH...

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Detalles Bibliográficos
Autores principales: Bugay, Vladislav, Wallace, Derek J., Wang, Bin, Salinas, Irving, Chapparo, Adriana Paola, Smith, Hudson Ryan, Dube, Peter Herbert, Brooks, Edward G., Berg, Kelly Ann, Brenner, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525093/
https://www.ncbi.nlm.nih.gov/pubmed/33041794
http://dx.doi.org/10.3389/fphar.2020.552211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525093/
https://www.ncbi.nlm.nih.gov/pubmed/33041794
http://dx.doi.org/10.3389/fphar.2020.552211

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