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The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
BACKGROUND: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive. METHODS: Our Mendelian Randomization analysis used the most recent genome-wide datasets focus...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525156/ https://www.ncbi.nlm.nih.gov/pubmed/33193614 http://dx.doi.org/10.3389/fgene.2020.540724 |
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author | Jung, Su Yon Mancuso, Nicholas Han, Sihao Zhang, Zuo-Feng |
author_facet | Jung, Su Yon Mancuso, Nicholas Han, Sihao Zhang, Zuo-Feng |
author_sort | Jung, Su Yon |
collection | PubMed |
description | BACKGROUND: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive. METHODS: Our Mendelian Randomization analysis used the most recent genome-wide datasets focusing on European women. RESULTS: Of 44 single-nucleotide polymorphisms (SNPs) with GTs, 38 fasting-glucose and 6 fasting-insulin SNPs showed heterogeneous associations with breast cancer, without significant directional pleiotropy observed. CONCLUSION: Our findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer. |
format | Online Article Text |
id | pubmed-7525156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75251562020-11-13 The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study Jung, Su Yon Mancuso, Nicholas Han, Sihao Zhang, Zuo-Feng Front Genet Genetics BACKGROUND: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive. METHODS: Our Mendelian Randomization analysis used the most recent genome-wide datasets focusing on European women. RESULTS: Of 44 single-nucleotide polymorphisms (SNPs) with GTs, 38 fasting-glucose and 6 fasting-insulin SNPs showed heterogeneous associations with breast cancer, without significant directional pleiotropy observed. CONCLUSION: Our findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer. Frontiers Media S.A. 2020-09-16 /pmc/articles/PMC7525156/ /pubmed/33193614 http://dx.doi.org/10.3389/fgene.2020.540724 Text en Copyright © 2020 Jung, Mancuso, Han and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Jung, Su Yon Mancuso, Nicholas Han, Sihao Zhang, Zuo-Feng The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study |
title | The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study |
title_full | The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study |
title_fullStr | The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study |
title_full_unstemmed | The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study |
title_short | The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study |
title_sort | role of genetically determined glycemic traits in breast cancer: a mendelian randomization study |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525156/ https://www.ncbi.nlm.nih.gov/pubmed/33193614 http://dx.doi.org/10.3389/fgene.2020.540724 |
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