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The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study

BACKGROUND: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive. METHODS: Our Mendelian Randomization analysis used the most recent genome-wide datasets focus...

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Autores principales: Jung, Su Yon, Mancuso, Nicholas, Han, Sihao, Zhang, Zuo-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525156/
https://www.ncbi.nlm.nih.gov/pubmed/33193614
http://dx.doi.org/10.3389/fgene.2020.540724
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author Jung, Su Yon
Mancuso, Nicholas
Han, Sihao
Zhang, Zuo-Feng
author_facet Jung, Su Yon
Mancuso, Nicholas
Han, Sihao
Zhang, Zuo-Feng
author_sort Jung, Su Yon
collection PubMed
description BACKGROUND: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive. METHODS: Our Mendelian Randomization analysis used the most recent genome-wide datasets focusing on European women. RESULTS: Of 44 single-nucleotide polymorphisms (SNPs) with GTs, 38 fasting-glucose and 6 fasting-insulin SNPs showed heterogeneous associations with breast cancer, without significant directional pleiotropy observed. CONCLUSION: Our findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer.
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spelling pubmed-75251562020-11-13 The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study Jung, Su Yon Mancuso, Nicholas Han, Sihao Zhang, Zuo-Feng Front Genet Genetics BACKGROUND: Circulating glycemic traits (GTs) have been considered a risk factor for breast cancer, but studies using GT-associated genetic variants as an instrumental variable are limited and inconclusive. METHODS: Our Mendelian Randomization analysis used the most recent genome-wide datasets focusing on European women. RESULTS: Of 44 single-nucleotide polymorphisms (SNPs) with GTs, 38 fasting-glucose and 6 fasting-insulin SNPs showed heterogeneous associations with breast cancer, without significant directional pleiotropy observed. CONCLUSION: Our findings indicate a null association between genetically determined GTs and breast cancer risk among European women. Our findings may contribute to more complete characterizing of metabolic pathways in GTs and breast cancer. Frontiers Media S.A. 2020-09-16 /pmc/articles/PMC7525156/ /pubmed/33193614 http://dx.doi.org/10.3389/fgene.2020.540724 Text en Copyright © 2020 Jung, Mancuso, Han and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Jung, Su Yon
Mancuso, Nicholas
Han, Sihao
Zhang, Zuo-Feng
The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
title The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
title_full The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
title_fullStr The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
title_full_unstemmed The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
title_short The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study
title_sort role of genetically determined glycemic traits in breast cancer: a mendelian randomization study
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525156/
https://www.ncbi.nlm.nih.gov/pubmed/33193614
http://dx.doi.org/10.3389/fgene.2020.540724
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