Cargando…

Evaluation of p16(INK4a) expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation

BACKGROUND: A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wagner, Steffen, Prigge, Elena-Sophie, Wuerdemann, Nora, Reder, Henrike, Bushnak, Ayman, Sharma, Shachi Jenny, Obermueller, Theresa, von Knebel Doeberitz, Magnus, Dreyer, Thomas, Gattenlöhner, Stefan, Wolf, Gregor, Pons-Kühnemann, Jörn, Wittekindt, Claus, Klussmann, Jens Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525437/ https://www.ncbi.nlm.nih.gov/pubmed/32624580 http://dx.doi.org/10.1038/s41416-020-0964-x

Ejemplares similares

Correction: Evaluation of p16(INK4a) expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation
por: Wagner, Steffen, et al.
Publicado: (2021)

Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer
por: Wagner, Steffen, et al.
Publicado: (2017)

Reply to ‘Comment on ‘Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer”
por: Wagner, Steffen, et al.
Publicado: (2018)

Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region
por: Wagner, Steffen, et al.
Publicado: (2023)

Prognostic Impact of AJCC/UICC 8th Edition New Staging Rules in Oropharyngeal Squamous Cell Carcinoma
por: Würdemann, Nora, et al.
Publicado: (2017)

HPV – A different view on Head and Neck Cancer
por: Wittekindt, Claus, et al.
Publicado: (2018)

Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status
por: Reder, Henrike, et al.
Publicado: (2021)

PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma
por: Wuerdemann, Nora, et al.
Publicado: (2020)

LAG-3, TIM-3 and VISTA Expression on Tumor-Infiltrating Lymphocytes in Oropharyngeal Squamous Cell Carcinoma—Potential Biomarkers for Targeted Therapy Concepts
por: Wuerdemann, Nora, et al.
Publicado: (2020)

Role of DNA methylation in HPV associated lesions
por: von Knebel Doeberitz, Magnus, et al.
Publicado: (2019)

A systematic review of the HPV‐attributable fraction of oropharyngeal squamous cell carcinomas in Germany
por: Reuschenbach, Miriam, et al.
Publicado: (2019)

Overexpression of p16(INK4a) Serves as Prognostic Marker in Squamous Cell Vulvar Cancer Patients Treated With Radiotherapy Irrespective of HPV-Status
por: Arians, Nathalie, et al.
Publicado: (2019)

Lymphocyte activation gene 3 (LAG3) protein expression on tumor-infiltrating lymphocytes in aggressive and TP53-mutated salivary gland carcinomas
por: Arolt, Christoph, et al.
Publicado: (2020)

Speicheldrüsenkarzinome – Monozentrische Erfahrung zu Subtypen und deren Inzidenz über 42 Jahre
por: Krauss, Christian, et al.
Publicado: (2022)

Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study
por: Grønhøj, Christian, et al.
Publicado: (2019)

Predicting HPV association using deep learning and regular H&E stains allows granular stratification of oropharyngeal cancer patients
por: Klein, Sebastian, et al.
Publicado: (2023)

Cell-Free HPV-DNA as a Biomarker for Oropharyngeal Squamous Cell Carcinoma—A Step Towards Personalized Medicine?
por: Wuerdemann, Nora, et al.
Publicado: (2020)

Upfront Surgery vs. Primary Chemoradiation in an Unselected, Bicentric Patient Cohort with Oropharyngeal Squamous Cell Carcinoma—A Matched-Pair Analysis
por: Zimmermann, Philipp H., et al.
Publicado: (2021)

Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)
por: Grønhøj, Christian, et al.
Publicado: (2018)

The rationale for HPV-related oropharyngeal cancer de-escalation treatment strategies
por: Wierzbicka, Małgorzata, et al.
Publicado: (2015)

Awareness of Human Papillomavirus (HPV) and HPV Vaccination amongst the General Population in Germany: Lack of Awareness and Need for Action
por: Sharma, Shachi Jenny, et al.
Publicado: (2022)

Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer
por: Preuss, S F, et al.
Publicado: (2008)

5-aza-2′-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells
por: Stich, Maximilian, et al.
Publicado: (2016)

Hypoxia-inducible factor-1α activation in HPV-positive head and neck squamous cell carcinoma cell lines
por: Knuth, Jennifer, et al.
Publicado: (2017)

Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand?
por: Mirghani, Haitham, et al.
Publicado: (2017)

Basics of tumor development and importance of human papilloma virus (HPV) for head and neck cancer
por: Wittekindt, Claus, et al.
Publicado: (2012)

Differential Methylation of the HPV 16 Upstream Regulatory Region during Epithelial Differentiation and Neoplastic Transformation
por: Vinokurova, Svetlana, et al.
Publicado: (2011)

Sex-specific aspects in patients with oropharyngeal squamous cell carcinoma: a bicentric cohort study
por: Klasen, Charlotte, et al.
Publicado: (2023)

What is the future of treatment de-escalation for HPV-positive oropharyngeal cancer? A review of ongoing clinical trials
por: Mensour, Emma A., et al.
Publicado: (2022)

Accuracy of high-risk HPV DNA PCR, p16((INK4a)) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer
por: Simoens, Cindy, et al.
Publicado: (2022)

Novel concepts in cervical cancer screening: a comparison of VIA, HPV DNA test and p16(INK4a)/Ki-67 dual stain cytology in Western Kenya
por: Orang’o, Elkanah Omenge, et al.
Publicado: (2020)

Impact of HPV in Oropharyngeal Cancer
por: Marklund, Linda, et al.
Publicado: (2011)

Causes and Consequences of HPV Integration in Head and Neck Squamous Cell Carcinomas: State of the Art
por: Balaji, Harini, et al.
Publicado: (2021)

Targeted Therapy as a Potential De-Escalation Strategy in Locally Advanced HPV-Associated Oropharyngeal Cancer: A Literature Review
por: Chitsike, Lennox, et al.
Publicado: (2021)

Concurrent cisplatin or cetuximab with radiotherapy for HPV-positive oropharyngeal cancer: Medical resource use, costs, and quality-adjusted survival from the De-ESCALaTE HPV trial
por: Jones, David A., et al.
Publicado: (2020)

Sensitive HPV detection in oropharyngeal cancers
por: Winder, David M, et al.
Publicado: (2009)

The immune response in HPV(+) oropharyngeal cancer
por: King, Emma V, et al.
Publicado: (2014)

Immunotherapy in HPV-Related Oropharyngeal Cancers
por: Roof, Logan, et al.
Publicado: (2023)

HPV-mediated oropharyngeal carcinogenesis: An overview
por: Patil†, Shankargouda
Publicado: (2022)

HPV+ Oropharyngeal Cancer in Waldenström Macroglobulinemia
por: Raslan, Shahm, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2mao1hund5ceblv0lvn3qu22nt