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Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling

BACKGROUND: Wisteria floribunda agglutinin (WFA)(+) Mac-2-binding protein (M2BPGi) is a novel serum marker for liver fibrosis. Although an elevated serum level of M2BPGi can predict development of hepatocellular carcinoma (HCC), the effect of M2BPGi on HCC remains unclear. There are no reports about...

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Detalles Bibliográficos
Autores principales: Dolgormaa, Gantumur, Harimoto, Norifumi, Ishii, Norihiro, Yamanaka, Takahiro, Hagiwara, Kei, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Araki, Kenichiro, Handa, Tadashi, Yokobori, Takehiko, Oyama, Tetsunari, Kuwano, Hiroyuki, Shirabe, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525442/
https://www.ncbi.nlm.nih.gov/pubmed/32624579
http://dx.doi.org/10.1038/s41416-020-0971-y