Successive Statistical and Structure-Based Modeling to Identify Chemically Novel Kinase Inhibitors

[Image: see text] Kinases are frequently studied in the context of anticancer drugs. Their involvement in cell responses, such as proliferation, differentiation, and apoptosis, makes them interesting subjects in multitarget drug design. In this study, a workflow is presented that models the bioactiv...

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Detalles Bibliográficos
Autores principales: Burggraaff, Lindsey, Lenselink, Eelke B., Jespers, Willem, van Engelen, Jesper, Bongers, Brandon J., González, Marina Gorostiola, Liu, Rongfang, Hoos, Holger H., van Vlijmen, Herman W. T., IJzerman, Adriaan P., van Westen, Gerard J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525794/
https://www.ncbi.nlm.nih.gov/pubmed/32343143
http://dx.doi.org/10.1021/acs.jcim.9b01204

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