Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis

Methotrexate (MTX) is widely used as an anticancer and anti-inflammtory drug for treating various types of cancer and autoimmune diseases. The optimal dose of MTX is known to inhibit the dihydrofolatereductase that hinders the replication of purines. The nanobiomedicine has been extensively explored...

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Autores principales: Yu, Wen-Jun, Huang, Dong-Xu, Liu, Shuang, Sha, Ying-Li, Gao, Feng-hui, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526065/
https://www.ncbi.nlm.nih.gov/pubmed/33042817
http://dx.doi.org/10.3389/fonc.2020.01734
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author Yu, Wen-Jun
Huang, Dong-Xu
Liu, Shuang
Sha, Ying-Li
Gao, Feng-hui
Liu, Hong
author_facet Yu, Wen-Jun
Huang, Dong-Xu
Liu, Shuang
Sha, Ying-Li
Gao, Feng-hui
Liu, Hong
author_sort Yu, Wen-Jun
collection PubMed
description Methotrexate (MTX) is widely used as an anticancer and anti-inflammtory drug for treating various types of cancer and autoimmune diseases. The optimal dose of MTX is known to inhibit the dihydrofolatereductase that hinders the replication of purines. The nanobiomedicine has been extensively explored in the past decade to develop myriad functional nanostructures to facilitate the delivery of therapeutic agents for various medical applications. This review is focused on understanding the design and development of MTX-loaded nanoparticles alongside the inclusion of recent findings for the treatment of cancers. In this paper, we have made a coordinated effort to show the potential of novel drug delivery systems by achieving effective and target-specific delivery of methotrexate.
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spelling pubmed-75260652020-10-09 Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis Yu, Wen-Jun Huang, Dong-Xu Liu, Shuang Sha, Ying-Li Gao, Feng-hui Liu, Hong Front Oncol Oncology Methotrexate (MTX) is widely used as an anticancer and anti-inflammtory drug for treating various types of cancer and autoimmune diseases. The optimal dose of MTX is known to inhibit the dihydrofolatereductase that hinders the replication of purines. The nanobiomedicine has been extensively explored in the past decade to develop myriad functional nanostructures to facilitate the delivery of therapeutic agents for various medical applications. This review is focused on understanding the design and development of MTX-loaded nanoparticles alongside the inclusion of recent findings for the treatment of cancers. In this paper, we have made a coordinated effort to show the potential of novel drug delivery systems by achieving effective and target-specific delivery of methotrexate. Frontiers Media S.A. 2020-09-16 /pmc/articles/PMC7526065/ /pubmed/33042817 http://dx.doi.org/10.3389/fonc.2020.01734 Text en Copyright © 2020 Yu, Huang, Liu, Sha, Gao and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yu, Wen-Jun
Huang, Dong-Xu
Liu, Shuang
Sha, Ying-Li
Gao, Feng-hui
Liu, Hong
Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis
title Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis
title_full Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis
title_fullStr Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis
title_full_unstemmed Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis
title_short Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis
title_sort polymeric nanoscale drug carriers mediate the delivery of methotrexate for developing therapeutic interventions against cancer and rheumatoid arthritis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526065/
https://www.ncbi.nlm.nih.gov/pubmed/33042817
http://dx.doi.org/10.3389/fonc.2020.01734
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