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Inhibition of let-7b-5p contributes to an anti-tumorigenic macrophage phenotype through the SOCS1/STAT pathway in prostate cancer

BACKGROUND: Dysfunction of microRNAs (miRNAs) is a major cause of aberrant expression of inflammatory cytokines and contributes to macrophage polarization. Proinflammatory M1 macrophages promote T helper (Th) 1 responses and show tumoricidal activity, whereas M2 macrophages display regulatory functi...

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Detalles Bibliográficos
Autores principales:	Rong, Jiping, Xu, Lu, Hu, Yinying, Liu, Fan, Yu, Yanrong, Guo, Hongyan, Ni, Xudong, Huang, Yanqin, Zhao, Lin, Wang, Zhigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526222/ https://www.ncbi.nlm.nih.gov/pubmed/33005103 http://dx.doi.org/10.1186/s12935-020-01563-7

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