Cargando…

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

BACKGROUND: Tau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically examined both the transcriptome and proteome or differentiated Tau- versus age-de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mangleburg, Carl Grant, Wu, Timothy, Yalamanchili, Hari K., Guo, Caiwei, Hsieh, Yi-Chen, Duong, Duc M., Dammer, Eric B., De Jager, Philip L., Seyfried, Nicholas T., Liu, Zhandong, Shulman, Joshua M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526226/ https://www.ncbi.nlm.nih.gov/pubmed/32993812 http://dx.doi.org/10.1186/s13024-020-00405-4

Ejemplares similares

TBK1 interacts with tau and enhances neurodegeneration in tauopathy
por: Abreha, Measho H., et al.
Publicado: (2021)

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease
por: Hsieh, Yi-Chen, et al.
Publicado: (2019)

A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders
por: Al-Ouran, Rami, et al.
Publicado: (2019)

Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates
por: Zhang, Hui, et al.
Publicado: (2022)

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity
por: Yu, Meigen, et al.
Publicado: (2023)

Tau Activates Transposable Elements in Alzheimer’s Disease
por: Guo, Caiwei, et al.
Publicado: (2018)

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease
por: Donovan, Laura E, et al.
Publicado: (2013)

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
por: Swarup, Vivek, et al.
Publicado: (2020)

Correction to: Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer’s disease
por: Donovan, Laura E., et al.
Publicado: (2021)

Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease
por: Higginbotham, Lenora, et al.
Publicado: (2019)

Genetic background influences the 5XFAD Alzheimer’s disease mouse model brain proteome
por: Hurst, Cheyenne D., et al.
Publicado: (2023)

Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer’s Disease
por: Hurst, Cheyenne, et al.
Publicado: (2023)

Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome
por: Hurst, Cheyenne D., et al.
Publicado: (2023)

Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome
por: Dammer, Eric B., et al.
Publicado: (2022)

Biochemical isolation of myonuclei employed to define changes to the myonuclear proteome that occur with aging
por: Cutler, Alicia A., et al.
Publicado: (2017)

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease
por: Dai, Jingting, et al.
Publicado: (2018)

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain
por: Umoh, Mfon E, et al.
Publicado: (2017)

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
por: Koren, Shon A., et al.
Publicado: (2021)

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
por: Johnson, Erik C. B., et al.
Publicado: (2018)

Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction
por: Bar, Sudipta, et al.
Publicado: (2023)

Proteomics of protein post-translational modifications implicated in neurodegeneration
por: Ren, Ru-Jing, et al.
Publicado: (2014)

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations
por: Huang, Meixiang, et al.
Publicado: (2020)

Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer’s disease
por: Modeste, Erica S., et al.
Publicado: (2023)

Brain Cell Type-Specific Nuclear Proteomics Is Imperative to Resolve Neurodegenerative Disease Mechanisms
por: Nelson, Ruth S., et al.
Publicado: (2022)

Cellular Proteomic Profiling Using Proximity Labeling by TurboID-NES in Microglial and Neuronal Cell Lines
por: Sunna, Sydney, et al.
Publicado: (2023)

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
por: Wingo, Aliza P., et al.
Publicado: (2021)

A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy
por: Gutierrez-Quiceno, Laura, et al.
Publicado: (2021)

Brain proteome-wide association study implicates novel proteins in depression pathogenesis
por: Wingo, Thomas S., et al.
Publicado: (2021)

Identification of risk genes for Alzheimer’s disease by gene embedding
por: Lagisetty, Yashwanth, et al.
Publicado: (2022)

A Comprehensive and Integrative Approach to MeCP2 Disease Transcriptomics
por: Trostle, Alexander J., et al.
Publicado: (2023)

Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
por: Ping, Lingyan, et al.
Publicado: (2018)

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
por: Higginbotham, Lenora, et al.
Publicado: (2020)

Osteopontin Is a Blood Biomarker for Microglial Activation and Brain Injury in Experimental Hypoxic-Ischemic Encephalopathy
por: Li, Yikun, et al.
Publicado: (2017)

Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue
por: Werner, Erica, et al.
Publicado: (2019)

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
por: Wang, Minghui, et al.
Publicado: (2018)

Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease
por: Guo, Qi, et al.
Publicado: (2021)

Tau polarizes an aging transcriptional signature to excitatory neurons and glia
por: Wu, Timothy, et al.
Publicado: (2023)

Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease
por: Ping, Lingyan, et al.
Publicado: (2020)

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
por: Wingo, Aliza P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_g09kdvff0l0h7qom5peoa6vab1