How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients

Pediatric allogeneic hematopoietic cell transplant (HCT) survival is limited by the development of post-transplant infections. In this overview, we discuss a clinical approach to the prompt recognition and treatment of fever and hypotension in pediatric HCT patients. Special attention is paid to ind...

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Detalles Bibliográficos
Autores principales: Zinter, Matt S., Dvorak, Christopher C., Auletta, Jeffery J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526343/
https://www.ncbi.nlm.nih.gov/pubmed/33042850
http://dx.doi.org/10.3389/fonc.2020.581447
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author Zinter, Matt S.
Dvorak, Christopher C.
Auletta, Jeffery J.
author_facet Zinter, Matt S.
Dvorak, Christopher C.
Auletta, Jeffery J.
author_sort Zinter, Matt S.
collection PubMed
description Pediatric allogeneic hematopoietic cell transplant (HCT) survival is limited by the development of post-transplant infections. In this overview, we discuss a clinical approach to the prompt recognition and treatment of fever and hypotension in pediatric HCT patients. Special attention is paid to individualized hemodynamic resuscitation, thorough diagnostic testing, novel anti-pathogen therapies, and the multimodal support required for recovery. We present three case vignettes that illustrate the complexities of post-HCT sepsis and highlight best practices that contribute to optimal transplant survival in children.
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spelling pubmed-75263432020-10-09 How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients Zinter, Matt S. Dvorak, Christopher C. Auletta, Jeffery J. Front Oncol Oncology Pediatric allogeneic hematopoietic cell transplant (HCT) survival is limited by the development of post-transplant infections. In this overview, we discuss a clinical approach to the prompt recognition and treatment of fever and hypotension in pediatric HCT patients. Special attention is paid to individualized hemodynamic resuscitation, thorough diagnostic testing, novel anti-pathogen therapies, and the multimodal support required for recovery. We present three case vignettes that illustrate the complexities of post-HCT sepsis and highlight best practices that contribute to optimal transplant survival in children. Frontiers Media S.A. 2020-09-16 /pmc/articles/PMC7526343/ /pubmed/33042850 http://dx.doi.org/10.3389/fonc.2020.581447 Text en Copyright © 2020 Zinter, Dvorak and Auletta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zinter, Matt S.
Dvorak, Christopher C.
Auletta, Jeffery J.
How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients
title How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients
title_full How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients
title_fullStr How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients
title_full_unstemmed How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients
title_short How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients
title_sort how we treat fever and hypotension in pediatric hematopoietic cell transplant patients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526343/
https://www.ncbi.nlm.nih.gov/pubmed/33042850
http://dx.doi.org/10.3389/fonc.2020.581447
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