The role of microenvironment in tumor angiogenesis

Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor cells, surrounding cells, and secreted cytokines—provides a conducive environment for the gro...

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Autores principales: Jiang, Xianjie, Wang, Jie, Deng, Xiangying, Xiong, Fang, Zhang, Shanshan, Gong, Zhaojian, Li, Xiayu, Cao, Ke, Deng, Hao, He, Yi, Liao, Qianjin, Xiang, Bo, Zhou, Ming, Guo, Can, Zeng, Zhaoyang, Li, Guiyuan, Li, Xiaoling, Xiong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526376/
https://www.ncbi.nlm.nih.gov/pubmed/32993787
http://dx.doi.org/10.1186/s13046-020-01709-5
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author Jiang, Xianjie
Wang, Jie
Deng, Xiangying
Xiong, Fang
Zhang, Shanshan
Gong, Zhaojian
Li, Xiayu
Cao, Ke
Deng, Hao
He, Yi
Liao, Qianjin
Xiang, Bo
Zhou, Ming
Guo, Can
Zeng, Zhaoyang
Li, Guiyuan
Li, Xiaoling
Xiong, Wei
author_facet Jiang, Xianjie
Wang, Jie
Deng, Xiangying
Xiong, Fang
Zhang, Shanshan
Gong, Zhaojian
Li, Xiayu
Cao, Ke
Deng, Hao
He, Yi
Liao, Qianjin
Xiang, Bo
Zhou, Ming
Guo, Can
Zeng, Zhaoyang
Li, Guiyuan
Li, Xiaoling
Xiong, Wei
author_sort Jiang, Xianjie
collection PubMed
description Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor cells, surrounding cells, and secreted cytokines—provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome.
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spelling pubmed-75263762020-10-01 The role of microenvironment in tumor angiogenesis Jiang, Xianjie Wang, Jie Deng, Xiangying Xiong, Fang Zhang, Shanshan Gong, Zhaojian Li, Xiayu Cao, Ke Deng, Hao He, Yi Liao, Qianjin Xiang, Bo Zhou, Ming Guo, Can Zeng, Zhaoyang Li, Guiyuan Li, Xiaoling Xiong, Wei J Exp Clin Cancer Res Review Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor cells, surrounding cells, and secreted cytokines—provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome. BioMed Central 2020-09-30 /pmc/articles/PMC7526376/ /pubmed/32993787 http://dx.doi.org/10.1186/s13046-020-01709-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Jiang, Xianjie
Wang, Jie
Deng, Xiangying
Xiong, Fang
Zhang, Shanshan
Gong, Zhaojian
Li, Xiayu
Cao, Ke
Deng, Hao
He, Yi
Liao, Qianjin
Xiang, Bo
Zhou, Ming
Guo, Can
Zeng, Zhaoyang
Li, Guiyuan
Li, Xiaoling
Xiong, Wei
The role of microenvironment in tumor angiogenesis
title The role of microenvironment in tumor angiogenesis
title_full The role of microenvironment in tumor angiogenesis
title_fullStr The role of microenvironment in tumor angiogenesis
title_full_unstemmed The role of microenvironment in tumor angiogenesis
title_short The role of microenvironment in tumor angiogenesis
title_sort role of microenvironment in tumor angiogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526376/
https://www.ncbi.nlm.nih.gov/pubmed/32993787
http://dx.doi.org/10.1186/s13046-020-01709-5
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