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ANGPTL8 has both endocrine and autocrine effects on substrate utilization

The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required...

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Detalles Bibliográficos
Autores principales: Oldoni, Federico, Cheng, Haili, Banfi, Serena, Gusarova, Viktoria, Cohen, Jonathan C., Hobbs, Helen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526440/
https://www.ncbi.nlm.nih.gov/pubmed/32730227
http://dx.doi.org/10.1172/jci.insight.138777