Cargando…

CREB1 Suppresses Transcription of microRNA-186 to Promote Growth, Invasion and Epithelial–Mesenchymal Transition of Gastric Cancer Cells Through the KRT8/HIF-1α Axis

BACKGROUND: The cAMP response element-binding protein 1 (CREB1) was initiated as a potential target for cancer treatment. This research was conducted to probe the effect of CREB1 in the progression of gastric cancer (GC) and the molecules involved. MATERIALS AND METHODS: CREB1 expression in GC tissu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Xue, Liu, Fujian, Jiang, Zhiyong, Guan, Hang, Jia, Qiuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526476/ https://www.ncbi.nlm.nih.gov/pubmed/33061604 http://dx.doi.org/10.2147/CMAR.S265187

Ejemplares similares

KRT8 phosphorylation regulates the epithelial‐mesenchymal transition in retinal pigment epithelial cells through autophagy modulation
por: Miao, Qi, et al.
Publicado: (2020)

Long coding RNA CCAT2 enhances the proliferation and epithelial-mesenchymal transition of cervical carcinoma cells via the microRNA-493-5p/CREB1 axis
por: Wang, Jing, et al.
Publicado: (2021)

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition
por: Yang, Zhou, et al.
Publicado: (2019)

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond
por: Tam, Shing Yau, et al.
Publicado: (2020)

Correction to: SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition
por: Yang, Zhou, et al.
Publicado: (2023)

Inflammatory Cytokine-Induced HIF-1 Activation Promotes Epithelial–Mesenchymal Transition in Endometrial Epithelial Cells
por: Hashimoto, Yoshiko, et al.
Publicado: (2023)

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Analysis of KRT1, KRT10, KRT19, TP53 and MMP9 expression in pediatric and adult cholesteatoma
por: Palkó, Enikő, et al.
Publicado: (2018)

KRT7 promotes epithelial-mesenchymal transition in ovarian cancer via the TGF-β/Smad2/3 signaling pathway
por: An, Qiang, et al.
Publicado: (2021)

Hyperbaric Oxygen Therapy Represses the Warburg Effect and Epithelial–Mesenchymal Transition in Hypoxic NSCLC Cells via the HIF-1α/PFKP Axis
por: Zhang, Linling, et al.
Publicado: (2021)

The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition
por: Barriga, Elias H., et al.
Publicado: (2013)

A HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia
por: Percio, Stefano, et al.
Publicado: (2014)

LRG1 modulates epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1α activation
por: Zhang, Jingjing, et al.
Publicado: (2016)

HOXD-AS1 promotes the epithelial to mesenchymal transition of ovarian cancer cells by regulating miR-186-5p and PIK3R3
por: Dong, Shanshan, et al.
Publicado: (2019)

Infectious Knockdown of CREB and HIF-1 for the Treatment of Metastatic Uveal Melanoma
por: Voropaev, Hanna, et al.
Publicado: (2019)

Association of MALAT1 and PVT1 Variants, Expression Profiles and Target miRNA-101 and miRNA-186 with Colorectal Cancer: Correlation with Epithelial-Mesenchymal Transition
por: Radwan, Abdullah F., et al.
Publicado: (2021)

miR-186 regulates epithelial–mesenchymal transformation to promote nasopharyngeal carcinoma metastasis by targeting ZEB1()
por: Tang, Liangke, et al.
Publicado: (2023)

Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation
por: Kuony, Alison, et al.
Publicado: (2017)

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer
por: Zhang, Wenjing, et al.
Publicado: (2015)

MicroRNA Regulation of Epithelial to Mesenchymal Transition
por: Abba, Mohammed L., et al.
Publicado: (2016)

MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
por: Liu, L, et al.
Publicado: (2016)

MiR-186 inhibited aerobic glycolysis in gastric cancer via HIF-1α regulation
por: Liu, L, et al.
Publicado: (2017)

Hyperactivation of IL-6/STAT3 pathway leaded to the poor prognosis of post-TACE HCCs by HIF-1α/SNAI1 axis-induced epithelial to mesenchymal transition
por: Gai, Xiaohong, et al.
Publicado: (2020)

Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma
por: Zhang, Yan, et al.
Publicado: (2017)

HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway
por: Yang, Shi-wei, et al.
Publicado: (2017)

Emerging Role of CREB in Epithelial to Mesenchymal Plasticity of Pancreatic Cancer
por: Mehra, Siddharth, et al.
Publicado: (2022)

MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer
por: Chen, De, et al.
Publicado: (2015)

Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma
por: Shneor, D, et al.
Publicado: (2017)

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells
por: Chou, Chih-Chien, et al.
Publicado: (2015)

MicroRNAs and epithelial-mesenchymal transition in prostate cancer
por: Sekhon, Kirandeep, et al.
Publicado: (2016)

Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer
por: Legras, Antoine, et al.
Publicado: (2017)

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition
por: Eurlings, Irene M. J., et al.
Publicado: (2014)

Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway
por: Lei, Rui, et al.
Publicado: (2019)

CPEB2 Suppresses Hepatocellular Carcinoma Epithelial–Mesenchymal Transition and Metastasis through Regulating the HIF-1α/miR-210-3p/CPEB2 Axis
por: You, Ran, et al.
Publicado: (2023)

Upregulation of kazrin F by miR-186 suppresses apoptosis but promotes epithelial-mesenchymal transition to contribute to malignancy in human cervical cancer cells
por: Liu, Chang, et al.
Publicado: (2017)

Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway
por: Yan, Xianke, et al.
Publicado: (2020)

Potential role of HIF-1-responsive microRNA210/HIF3 axis on gemcitabine resistance in cholangiocarcinoma cells
por: Silakit, Runglawan, et al.
Publicado: (2018)

CRTC2 activates the epithelial–mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway
por: Li, Yujie, et al.
Publicado: (2023)

Anticancer Activity of Modified Tongyou Decoction on Eca109 Esophageal Cancer Cell Invasion and Metastasis through Regulation of the Epithelial-Mesenchymal Transition Mediated by the HIF-1α-Snail Axis
por: Jia, Yongsen, et al.
Publicado: (2020)

Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition
por: Wang, Tong-Hong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gombe7qcql90h62iepvfr9u2ek