ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO pathway. We demonstrated that the NUPR1 inhibitor ZZW-...

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Detalles Bibliográficos
Autores principales: Lan, Wenjun, Santofimia-Castaño, Patricia, Swayden, Mirna, Xia, Yi, Zhou, Zhengwei, Audebert, Stephane, Camoin, Luc, Huang, Can, Peng, Ling, Jiménez-Alesanco, Ana, Velázquez-Campoy, Adrián, Abián, Olga, Lomberk, Gwen, Urrutia, Raul, Rizzuti, Bruno, Geli, Vincent, Soubeyran, Philippe, Neira, José L., Iovanna, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526551/
https://www.ncbi.nlm.nih.gov/pubmed/32780723
http://dx.doi.org/10.1172/jci.insight.138117

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