Cargando…
IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease
Tumor necrosis factor-α (TNF-α)-inhibiting agents are a standard therapy for moderate-to-severe inflammatory bowel disease (IBD). IgA nephropathy in the setting of prolonged exposure to TNF-α inhibitors is a rare, clinically significant adverse event often overlooked by gastroenterologists but well...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526714/ https://www.ncbi.nlm.nih.gov/pubmed/33062795 http://dx.doi.org/10.14309/crj.0000000000000462 |
_version_ | 1783588922754859008 |
---|---|
author | Strobel, Thomas Ahmed, Waseem De la Sancha, Carlo Bohm, Matthew Fischer, Monika |
author_facet | Strobel, Thomas Ahmed, Waseem De la Sancha, Carlo Bohm, Matthew Fischer, Monika |
author_sort | Strobel, Thomas |
collection | PubMed |
description | Tumor necrosis factor-α (TNF-α)-inhibiting agents are a standard therapy for moderate-to-severe inflammatory bowel disease (IBD). IgA nephropathy in the setting of prolonged exposure to TNF-α inhibitors is a rare, clinically significant adverse event often overlooked by gastroenterologists but well documented in the rheumatologic literature. We present a case series of 3 patients with IBD on TNF-α inhibitors who developed biopsy-proven IgA nephropathy. Clinicians prescribing TNF-α inhibitors to patients with IBD need to be aware of this potential side effect. Therapies with alternative mechanisms of action should instead be considered. |
format | Online Article Text |
id | pubmed-7526714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-75267142020-10-14 IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease Strobel, Thomas Ahmed, Waseem De la Sancha, Carlo Bohm, Matthew Fischer, Monika ACG Case Rep J Case Report Tumor necrosis factor-α (TNF-α)-inhibiting agents are a standard therapy for moderate-to-severe inflammatory bowel disease (IBD). IgA nephropathy in the setting of prolonged exposure to TNF-α inhibitors is a rare, clinically significant adverse event often overlooked by gastroenterologists but well documented in the rheumatologic literature. We present a case series of 3 patients with IBD on TNF-α inhibitors who developed biopsy-proven IgA nephropathy. Clinicians prescribing TNF-α inhibitors to patients with IBD need to be aware of this potential side effect. Therapies with alternative mechanisms of action should instead be considered. Wolters Kluwer 2020-09-29 /pmc/articles/PMC7526714/ /pubmed/33062795 http://dx.doi.org/10.14309/crj.0000000000000462 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Case Report Strobel, Thomas Ahmed, Waseem De la Sancha, Carlo Bohm, Matthew Fischer, Monika IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease |
title | IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease |
title_full | IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease |
title_fullStr | IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease |
title_full_unstemmed | IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease |
title_short | IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease |
title_sort | iga nephropathy in the setting of anti-tnf-α therapy for inflammatory bowel disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526714/ https://www.ncbi.nlm.nih.gov/pubmed/33062795 http://dx.doi.org/10.14309/crj.0000000000000462 |
work_keys_str_mv | AT strobelthomas iganephropathyinthesettingofantitnfatherapyforinflammatoryboweldisease AT ahmedwaseem iganephropathyinthesettingofantitnfatherapyforinflammatoryboweldisease AT delasanchacarlo iganephropathyinthesettingofantitnfatherapyforinflammatoryboweldisease AT bohmmatthew iganephropathyinthesettingofantitnfatherapyforinflammatoryboweldisease AT fischermonika iganephropathyinthesettingofantitnfatherapyforinflammatoryboweldisease |