Impact of mutations in homologous recombination repair genes on treatment outcomes for metastatic castration resistant prostate cancer

INTRODUCTION: A significant proportion of patients with metastatic castration-resistant prostate cancer (mCRPC) harbor mutations in homologous recombination (HR) repair genes, with some of these mutations associating with increased tumor susceptibility to poly(ADP-ribose) polymerase (PARP) inhibitor...

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Detalles Bibliográficos
Autores principales: Carlson, Alexander S., Acevedo, Rigo I., Lim, Daniel M., Gulati, Roman, Gawne, Agnes, Sokolova, Alexandra O., Cheng, Heather H., Nelson, Peter S., Montgomery, R. Bruce, Yu, Evan Y., Schweizer, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526881/
https://www.ncbi.nlm.nih.gov/pubmed/32997692
http://dx.doi.org/10.1371/journal.pone.0239686

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