Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures

Mutations in BRCA1 and BRCA2 cause deficiencies in homologous recombination repair (HR), resulting in repair of DNA double-strand breaks by the alternative non-homologous end-joining pathway, which is more error prone. HR deficiency of breast tumors is important because it is associated with better...

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Detalles Bibliográficos
Autores principales: Bodily, Weston R., Shirts, Brian H., Walsh, Tom, Gulsuner, Suleyman, King, Mary-Claire, Parker, Alyssa, Roosan, Moom, Piccolo, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526916/
https://www.ncbi.nlm.nih.gov/pubmed/32997669
http://dx.doi.org/10.1371/journal.pone.0239197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526916/
https://www.ncbi.nlm.nih.gov/pubmed/32997669
http://dx.doi.org/10.1371/journal.pone.0239197

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