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Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?
Objective Inflammation plays an important role in the pathophysiology of disc herniation. The aim of this study was to evaluate blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) levels in cervical disc herniation (CDH) patients. Materials and meth...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526961/ https://www.ncbi.nlm.nih.gov/pubmed/33014656 http://dx.doi.org/10.7759/cureus.10161 |
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author | Ethemoğlu, Kadri Burak Erkoç, Yavuz Selim |
author_facet | Ethemoğlu, Kadri Burak Erkoç, Yavuz Selim |
author_sort | Ethemoğlu, Kadri Burak |
collection | PubMed |
description | Objective Inflammation plays an important role in the pathophysiology of disc herniation. The aim of this study was to evaluate blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) levels in cervical disc herniation (CDH) patients. Materials and methods We retrospectively analyzed the medical records of 126 patients with neck pain who were treated as inpatients at the Neurosurgery Department of Harran University Faculty of Medicine. The NLR, PLR, and CRP levels during hospital admissions were documented. Results The study included 73 patients with CDH and neck pain, 53 patients with normal cervical MR examination and neck pain, and 50 healthy control subjects. The group with cervical disc hernia had a significantly higher mean serum leucocyte count, neutrophil count, NLR, and CRP level compared to those with a normal MR but neck pain and the control group. NLR was significantly higher in the multi-level CDH group compared to the control group, while the single-level CDH and multi-level CDH had no significant difference with respect to mean serum inflammatory parameters. Conclusion Higher NLR and CRP in patients with CDH compared to patients with neck pain but normal cervical MR and the controls may be due to a developing inflammatory response. It may be speculated that among patients with neck pain, those with non-elevated NLR and CRP levels may have normal neck MR imaging, and in patients with elevated NLR and CRP levels, early protective approaches may play a preventive role in disc degeneration and cervical disc hernia development. |
format | Online Article Text |
id | pubmed-7526961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-75269612020-10-01 Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? Ethemoğlu, Kadri Burak Erkoç, Yavuz Selim Cureus Neurosurgery Objective Inflammation plays an important role in the pathophysiology of disc herniation. The aim of this study was to evaluate blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) levels in cervical disc herniation (CDH) patients. Materials and methods We retrospectively analyzed the medical records of 126 patients with neck pain who were treated as inpatients at the Neurosurgery Department of Harran University Faculty of Medicine. The NLR, PLR, and CRP levels during hospital admissions were documented. Results The study included 73 patients with CDH and neck pain, 53 patients with normal cervical MR examination and neck pain, and 50 healthy control subjects. The group with cervical disc hernia had a significantly higher mean serum leucocyte count, neutrophil count, NLR, and CRP level compared to those with a normal MR but neck pain and the control group. NLR was significantly higher in the multi-level CDH group compared to the control group, while the single-level CDH and multi-level CDH had no significant difference with respect to mean serum inflammatory parameters. Conclusion Higher NLR and CRP in patients with CDH compared to patients with neck pain but normal cervical MR and the controls may be due to a developing inflammatory response. It may be speculated that among patients with neck pain, those with non-elevated NLR and CRP levels may have normal neck MR imaging, and in patients with elevated NLR and CRP levels, early protective approaches may play a preventive role in disc degeneration and cervical disc hernia development. Cureus 2020-08-31 /pmc/articles/PMC7526961/ /pubmed/33014656 http://dx.doi.org/10.7759/cureus.10161 Text en Copyright © 2020, Ethemoğlu et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurosurgery Ethemoğlu, Kadri Burak Erkoç, Yavuz Selim Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? |
title | Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? |
title_full | Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? |
title_fullStr | Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? |
title_full_unstemmed | Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? |
title_short | Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? |
title_sort | is there any relationship between cervical disc herniation and blood inflammatory response? |
topic | Neurosurgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526961/ https://www.ncbi.nlm.nih.gov/pubmed/33014656 http://dx.doi.org/10.7759/cureus.10161 |
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