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Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?

Objective Inflammation plays an important role in the pathophysiology of disc herniation. The aim of this study was to evaluate blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) levels in cervical disc herniation (CDH) patients. Materials and meth...

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Autores principales: Ethemoğlu, Kadri Burak, Erkoç, Yavuz Selim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526961/
https://www.ncbi.nlm.nih.gov/pubmed/33014656
http://dx.doi.org/10.7759/cureus.10161
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author Ethemoğlu, Kadri Burak
Erkoç, Yavuz Selim
author_facet Ethemoğlu, Kadri Burak
Erkoç, Yavuz Selim
author_sort Ethemoğlu, Kadri Burak
collection PubMed
description Objective Inflammation plays an important role in the pathophysiology of disc herniation. The aim of this study was to evaluate blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) levels in cervical disc herniation (CDH) patients. Materials and methods We retrospectively analyzed the medical records of 126 patients with neck pain who were treated as inpatients at the Neurosurgery Department of Harran University Faculty of Medicine. The NLR, PLR, and CRP levels during hospital admissions were documented. Results The study included 73 patients with CDH and neck pain, 53 patients with normal cervical MR examination and neck pain, and 50 healthy control subjects. The group with cervical disc hernia had a significantly higher mean serum leucocyte count, neutrophil count, NLR, and CRP level compared to those with a normal MR but neck pain and the control group. NLR was significantly higher in the multi-level CDH group compared to the control group, while the single-level CDH and multi-level CDH had no significant difference with respect to mean serum inflammatory parameters. Conclusion Higher NLR and CRP in patients with CDH compared to patients with neck pain but normal cervical MR and the controls may be due to a developing inflammatory response. It may be speculated that among patients with neck pain, those with non-elevated NLR and CRP levels may have normal neck MR imaging, and in patients with elevated NLR and CRP levels, early protective approaches may play a preventive role in disc degeneration and cervical disc hernia development.
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spelling pubmed-75269612020-10-01 Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response? Ethemoğlu, Kadri Burak Erkoç, Yavuz Selim Cureus Neurosurgery Objective Inflammation plays an important role in the pathophysiology of disc herniation. The aim of this study was to evaluate blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-reactive protein (CRP) levels in cervical disc herniation (CDH) patients. Materials and methods We retrospectively analyzed the medical records of 126 patients with neck pain who were treated as inpatients at the Neurosurgery Department of Harran University Faculty of Medicine. The NLR, PLR, and CRP levels during hospital admissions were documented. Results The study included 73 patients with CDH and neck pain, 53 patients with normal cervical MR examination and neck pain, and 50 healthy control subjects. The group with cervical disc hernia had a significantly higher mean serum leucocyte count, neutrophil count, NLR, and CRP level compared to those with a normal MR but neck pain and the control group. NLR was significantly higher in the multi-level CDH group compared to the control group, while the single-level CDH and multi-level CDH had no significant difference with respect to mean serum inflammatory parameters. Conclusion Higher NLR and CRP in patients with CDH compared to patients with neck pain but normal cervical MR and the controls may be due to a developing inflammatory response. It may be speculated that among patients with neck pain, those with non-elevated NLR and CRP levels may have normal neck MR imaging, and in patients with elevated NLR and CRP levels, early protective approaches may play a preventive role in disc degeneration and cervical disc hernia development. Cureus 2020-08-31 /pmc/articles/PMC7526961/ /pubmed/33014656 http://dx.doi.org/10.7759/cureus.10161 Text en Copyright © 2020, Ethemoğlu et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurosurgery
Ethemoğlu, Kadri Burak
Erkoç, Yavuz Selim
Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?
title Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?
title_full Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?
title_fullStr Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?
title_full_unstemmed Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?
title_short Is There Any Relationship Between Cervical Disc Herniation and Blood Inflammatory Response?
title_sort is there any relationship between cervical disc herniation and blood inflammatory response?
topic Neurosurgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526961/
https://www.ncbi.nlm.nih.gov/pubmed/33014656
http://dx.doi.org/10.7759/cureus.10161
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