The Scribble family in cancer: twentieth anniversary

Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic scaffold Scribble stands out because of its essential role in many steps of cancer development and dissemination. Its fame has somehow blurred the importance of homologous proteins, Erbin and Lano, all belonging to...

Descripción completa

Detalles Bibliográficos
Autores principales: Santoni, Marie-Josée, Kashyap, Rudra, Camoin, Luc, Borg, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527152/
https://www.ncbi.nlm.nih.gov/pubmed/32999444
http://dx.doi.org/10.1038/s41388-020-01478-7
_version_ 1783588996652204032
author Santoni, Marie-Josée
Kashyap, Rudra
Camoin, Luc
Borg, Jean-Paul
author_facet Santoni, Marie-Josée
Kashyap, Rudra
Camoin, Luc
Borg, Jean-Paul
author_sort Santoni, Marie-Josée
collection PubMed
description Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic scaffold Scribble stands out because of its essential role in many steps of cancer development and dissemination. Its fame has somehow blurred the importance of homologous proteins, Erbin and Lano, all belonging to the LRR and PDZ (LAP) protein family first described twenty years ago. In this review, we will retrace the history of LAP family protein research and draw attention to their contribution in cancer by detailing the features of its members at the structural and functional levels, and highlighting their shared—but also different—implication in the tumoral process.
format Online
Article
Text
id pubmed-7527152
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-75271522020-10-01 The Scribble family in cancer: twentieth anniversary Santoni, Marie-Josée Kashyap, Rudra Camoin, Luc Borg, Jean-Paul Oncogene Review Article Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic scaffold Scribble stands out because of its essential role in many steps of cancer development and dissemination. Its fame has somehow blurred the importance of homologous proteins, Erbin and Lano, all belonging to the LRR and PDZ (LAP) protein family first described twenty years ago. In this review, we will retrace the history of LAP family protein research and draw attention to their contribution in cancer by detailing the features of its members at the structural and functional levels, and highlighting their shared—but also different—implication in the tumoral process. Nature Publishing Group UK 2020-09-30 2020 /pmc/articles/PMC7527152/ /pubmed/32999444 http://dx.doi.org/10.1038/s41388-020-01478-7 Text en © The Author(s), under exclusive licence to Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Santoni, Marie-Josée
Kashyap, Rudra
Camoin, Luc
Borg, Jean-Paul
The Scribble family in cancer: twentieth anniversary
title The Scribble family in cancer: twentieth anniversary
title_full The Scribble family in cancer: twentieth anniversary
title_fullStr The Scribble family in cancer: twentieth anniversary
title_full_unstemmed The Scribble family in cancer: twentieth anniversary
title_short The Scribble family in cancer: twentieth anniversary
title_sort scribble family in cancer: twentieth anniversary
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527152/
https://www.ncbi.nlm.nih.gov/pubmed/32999444
http://dx.doi.org/10.1038/s41388-020-01478-7
work_keys_str_mv AT santonimariejosee thescribblefamilyincancertwentiethanniversary
AT kashyaprudra thescribblefamilyincancertwentiethanniversary
AT camoinluc thescribblefamilyincancertwentiethanniversary
AT borgjeanpaul thescribblefamilyincancertwentiethanniversary
AT santonimariejosee scribblefamilyincancertwentiethanniversary
AT kashyaprudra scribblefamilyincancertwentiethanniversary
AT camoinluc scribblefamilyincancertwentiethanniversary
AT borgjeanpaul scribblefamilyincancertwentiethanniversary

Ejemplares similares