PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning

The mechanism(s) through which mammalian kinase MELK promotes tumorigenesis is not understood. We find that the C. elegans orthologue of MELK, PIG-1, promotes apoptosis by partitioning an anti-apoptotic factor. The C. elegans NSM neuroblast divides to produce a larger cell that differentiates into a...

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Detalles Bibliográficos
Autores principales: Wei, Hai, Lambie, Eric J., Osório, Daniel S., Carvalho, Ana X., Conradt, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527206/
https://www.ncbi.nlm.nih.gov/pubmed/32946434
http://dx.doi.org/10.1371/journal.pgen.1008912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527206/
https://www.ncbi.nlm.nih.gov/pubmed/32946434
http://dx.doi.org/10.1371/journal.pgen.1008912

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