SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19

BACKGROUND AND AIMS: Besides prominent respiratory involvement, gastrointestinal manifestations are commonly reported in Coronavirus Disease 2019 (COVID-19) patients. We compared infection of ex vivo human intestinal tissues by SARS-CoV-2 and SARS-CoV with respect to their replication kinetics and i...

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Detalles Bibliográficos
Autores principales: Chu, Hin, Chan, Jasper Fuk-Woo, Wang, Yixin, Yuen, Terrence Tsz-Tai, Chai, Yue, Shuai, Huiping, Yang, Dong, Hu, Bingjie, Huang, Xiner, Zhang, Xi, Hou, Yuxin, Cai, Jian-Piao, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, To, Kelvin Kai-Wang, Hung, Ivan Fan-Ngai, Cheung, Tan To, Ng, Ada Tsui-Lin, Hau-Yee Chan, Ivy, Wong, Ian Yu-Hong, Law, Simon Ying-Kit, Foo, Dominic Chi-Chung, Leung, Wai-Keung, Yuen, Kwok-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527315/
https://www.ncbi.nlm.nih.gov/pubmed/33010495
http://dx.doi.org/10.1016/j.jcmgh.2020.09.017

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