Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors

Two recurrent mutations, K27M and G34R/V, in H3F3A, encoding non-canonical histone H3.3, are reported in pediatric and young adult gliomas, whereas G34W mutation is prevalent in bone tumors. In contrast to K27M mutation, it remains elusive how G34 mutations affect the epigenome. Here we performed wh...

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Detalles Bibliográficos
Autores principales: Sangatsuda, Yuhei, Miura, Fumihito, Araki, Hiromitsu, Mizoguchi, Masahiro, Hata, Nobuhiro, Kuga, Daisuke, Hatae, Ryusuke, Akagi, Yojiro, Amemiya, Takeo, Fujioka, Yutaka, Arai, Yasuhito, Yoshida, Akihiko, Shibata, Tatsuhiro, Yoshimoto, Koji, Iihara, Koji, Ito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527345/
https://www.ncbi.nlm.nih.gov/pubmed/32999376
http://dx.doi.org/10.1038/s41598-020-73116-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527345/
https://www.ncbi.nlm.nih.gov/pubmed/32999376
http://dx.doi.org/10.1038/s41598-020-73116-x

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