Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season

Neuraminidase inhibitor (NAI) resistance levels globally are currently low. However, as antivirals are increasingly being used, and even in the absence of selective pressure, resistance may increase or emerge. The neuraminidase (NA) genes from influenza viruses from the Irish 2018/2019 season were s...

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Autores principales: Brehony, Carina, Dunford, Linda, Bennett, Charlene, O’Donnell, Joan, Domegan, Lisa, McNamara, Eleanor, De Gascun, Cillian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527353/
https://www.ncbi.nlm.nih.gov/pubmed/33038626
http://dx.doi.org/10.1016/j.jcv.2020.104653
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author Brehony, Carina
Dunford, Linda
Bennett, Charlene
O’Donnell, Joan
Domegan, Lisa
McNamara, Eleanor
De Gascun, Cillian F.
author_facet Brehony, Carina
Dunford, Linda
Bennett, Charlene
O’Donnell, Joan
Domegan, Lisa
McNamara, Eleanor
De Gascun, Cillian F.
author_sort Brehony, Carina
collection PubMed
description Neuraminidase inhibitor (NAI) resistance levels globally are currently low. However, as antivirals are increasingly being used, and even in the absence of selective pressure, resistance may increase or emerge. The neuraminidase (NA) genes from influenza viruses from the Irish 2018/2019 season were sequenced: 1/144 (0.7 %) A(H1N1)pdm09 sequences harboured a substitution associated with highly-reduced susceptibility to NAIs. The very low NAI resistance we describe supports current Irish NAI use recommendations. However, continued monitoring is essential. NA characterisation also identified substitutions associated with reduced antibody effectiveness, thereby highlighting the potential of NA sequence surveillance as an additional tool for investigating influenza vaccine effectiveness (VE).
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spelling pubmed-75273532020-10-01 Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season Brehony, Carina Dunford, Linda Bennett, Charlene O’Donnell, Joan Domegan, Lisa McNamara, Eleanor De Gascun, Cillian F. J Clin Virol Short Communication Neuraminidase inhibitor (NAI) resistance levels globally are currently low. However, as antivirals are increasingly being used, and even in the absence of selective pressure, resistance may increase or emerge. The neuraminidase (NA) genes from influenza viruses from the Irish 2018/2019 season were sequenced: 1/144 (0.7 %) A(H1N1)pdm09 sequences harboured a substitution associated with highly-reduced susceptibility to NAIs. The very low NAI resistance we describe supports current Irish NAI use recommendations. However, continued monitoring is essential. NA characterisation also identified substitutions associated with reduced antibody effectiveness, thereby highlighting the potential of NA sequence surveillance as an additional tool for investigating influenza vaccine effectiveness (VE). Published by Elsevier B.V. 2020-11 2020-10-01 /pmc/articles/PMC7527353/ /pubmed/33038626 http://dx.doi.org/10.1016/j.jcv.2020.104653 Text en © 2020 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Brehony, Carina
Dunford, Linda
Bennett, Charlene
O’Donnell, Joan
Domegan, Lisa
McNamara, Eleanor
De Gascun, Cillian F.
Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season
title Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season
title_full Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season
title_fullStr Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season
title_full_unstemmed Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season
title_short Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season
title_sort neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the irish influenza 2018/2019 season
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527353/
https://www.ncbi.nlm.nih.gov/pubmed/33038626
http://dx.doi.org/10.1016/j.jcv.2020.104653
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