A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney

Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain glomerular integrity, is a pivotal prerequisite for therapeutic interventions. The alpha-8...

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Autores principales: Marek, Ines, Hilgers, Karl Friedrich, Rascher, Wolfgang, Woelfle, Joachim, Hartner, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527396/
https://www.ncbi.nlm.nih.gov/pubmed/33000355
http://dx.doi.org/10.1186/s40348-020-00105-5
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author Marek, Ines
Hilgers, Karl Friedrich
Rascher, Wolfgang
Woelfle, Joachim
Hartner, Andrea
author_facet Marek, Ines
Hilgers, Karl Friedrich
Rascher, Wolfgang
Woelfle, Joachim
Hartner, Andrea
author_sort Marek, Ines
collection PubMed
description Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain glomerular integrity, is a pivotal prerequisite for therapeutic interventions. The alpha-8 integrin chain seems to be an important player to maintain glomerular homeostasis by conferring mechanical stability and functional support for the renal capillary tuft.
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spelling pubmed-75273962020-10-19 A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney Marek, Ines Hilgers, Karl Friedrich Rascher, Wolfgang Woelfle, Joachim Hartner, Andrea Mol Cell Pediatr Mini Review Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain glomerular integrity, is a pivotal prerequisite for therapeutic interventions. The alpha-8 integrin chain seems to be an important player to maintain glomerular homeostasis by conferring mechanical stability and functional support for the renal capillary tuft. Springer Berlin Heidelberg 2020-10-01 /pmc/articles/PMC7527396/ /pubmed/33000355 http://dx.doi.org/10.1186/s40348-020-00105-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Mini Review
Marek, Ines
Hilgers, Karl Friedrich
Rascher, Wolfgang
Woelfle, Joachim
Hartner, Andrea
A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
title A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
title_full A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
title_fullStr A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
title_full_unstemmed A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
title_short A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
title_sort role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527396/
https://www.ncbi.nlm.nih.gov/pubmed/33000355
http://dx.doi.org/10.1186/s40348-020-00105-5
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